Aritcle: PDF OnlyStudies on the relationship between 'antiphospholipid' antibodies and the lupus anticoagulantExner, Thomas; McRea, JohnAuthor Information T. Exner is with the Haematology Department, Westmead Hospital, Sydney, NSW 2145: J. McRae was formerly with the Department of Rheumatology, University of Sydney, and is now in the Rheumatology Department at the Belfast City Hospital, Northern Ireland. Blood Coagulation & Fibrinolysis: March 1990 - Volume 1 - Issue 1 - p 17-22 Buy Abstract The correlation between lupus anticoagulant (LA) potency and anticardiolipin antibody (ACA) ELISA was found to be poor (r = 0.40) in a group of 56 patients accumulated by a haematology department mainly for studies of LA. This correlation was similar whether LAs were assessed by kaolin clotting time or activated partial thromboplastin time increments. When the more procoagulant phospholipid phosphatidyl serine, used in a calcium-containing buffer, was substituted for cardiolipin in the ELISA, the correlation with LA was only slightly improved (r = 0.58). In fact, binding of antibody from patient plasmas to blank wells, although quantitatively reduced, was found to correlate equally well with LA activity. LAs ate not necessarily phospholipid-binding antibodies but may interfere more generally with other surface-dependent processes in the clotting mechanism. © Lippincott-Raven Publishers.