Research report: PDF OnlyNeuroprotective effect of chronic administration of cannabidiol during the abstinence period on methamphetamine-induced impairment of recognition memory in the ratsRazavi, Yasamana; Shabani, Ronaka,,b; Mehdizadeh, Mehdib,,*; Haghparast, Abbasc,,*Author Information aCellular and Molecular Research Center bDepartment of Anatomy, School of Medicine, Iran University of Medical Sciences cNeuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran * Abbas Haghparast and Mehdi Mehdizadeh contributed equally to the writing of this article. Received 4 August 2019 Accepted 18 December 2019 Correspondence to Abbas Haghparast, PhD, Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, P.O. Box 19615-1178, Tehran, Iran, E-mail: email@example.com; firstname.lastname@example.org Behavioural Pharmacology: February 4, 2020 - Volume Publish Ahead of Print - Issue - doi: 10.1097/FBP.0000000000000544 Buy PAP Metrics Abstract Neuropsychiatric disorders, such as addiction, are associated with cognitive impairment, including learning and memory deficits. Previous research has demonstrated that the chronic use of methamphetamine (METH) induces long-term cognitive impairment and cannabidiol (CBD), as a neuroprotectant, can reverse spatial memory deficits induced by drug abuse. The study aimed to evaluate the effect of CBD on METH-induced memory impairment in rats chronically exposed to METH (CEM). For the induction of CEM, animals received METH (2 mg/kg, twice/day) for 10 days. Thereafter, the effect of intracerebroventricular (ICV) administration of CBD (32 and 160 nmol) during the (10 days) abstinence period on spatial memory was evaluated using the Y-Maze test, while recognition memory was examined using the novel object recognition (NOR) test. The results revealed a significant increase in the motor activity of METH-treated animals compared with the control group and, after the 10-day abstinence period, motor activity returned to baseline. Notably, the chronic administration of METH had impairing effects on spontaneous alternation performance and recognition memory, which was clearly observed in the NOR test. Additionally, although the ICV administration of CBD (160 nmol) could reverse long-term memory, a lower dose (32 nmol) did not result in any significant increase in exploring the novel object during short-term memory testing. These novel findings suggest that the chronic administration of METH induces memory impairment and presents interesting implications for the potential use of CBD in treating impairment deficits after chronic exposure to psychostimulant drugs such as METH. Copyright © 2020 YEAR Wolters Kluwer Health, Inc. All rights reserved.