Research ReportsPreference for vigorous exercise versus sedentary sucrose drinking: an animal model of anergia induced by dopamine receptor antagonismCorrea, Mercèa,,b; Pardo, Martac; Carratalá-Ros, Carlaa; Martínez-Verdú, Andreaa; Salamone, John D.bAuthor Information aÀrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, Castelló, Spain bDepartment of Psychology, University of Connecticut, Storrs, Connecticut cDepartment of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA Received 11 May 2019 Accepted as revised 5 February 2020 Correspondence to Dr. Mercè Correa, Àrea de Psicobiologia, Campus de Riu Sec, Universitat Jaume I, 12071 Castelló, Spain, E-mail: firstname.lastname@example.org Behavioural Pharmacology: September 2020 - Volume 31 - Issue 6 - p 553-564 doi: 10.1097/FBP.0000000000000556 Buy Metrics Abstract Motivation has activational and directional components. Mesolimbic dopamine is critical for the regulation of behavioral activation and effort-related processes in motivated behaviors. Impairing mesolimbic dopamine function leads to fatigue and anergia, but leaves intact other aspects of reinforce seeking behaviors, such as the consummatory or hedonic component. In male Swiss mice, we characterized the impact of dopamine antagonism on the selection of concurrently presented stimuli that have different vigor requirements. We analyzed running wheel activity versus sucrose solution intake, typically used as a measure of anhedonia. Results are compared with data from nonconcurrent presentation to those stimuli. In the concurrent presentation experiment, control mice preferred to spend time running compared to sucrose intake. Dopamine antagonism shifted relative reinforcer preference, reducing time spent on the running wheel, but actually increasing time-consuming sucrose. Mice increased frequency of bouts for both reinforcers, suggesting that there was fatigue in the running wheel rather than aversion. Moreover, satiation or habituation by preexposing animals to both reinforcers did not shift preferences. In the nonconcurrent experiments, haloperidol reduced running wheel but had no impact on sucrose consumption. Dopamine antagonism did not change preference for sucrose or total volume consumed. Additional correlational analyses indicated that baseline differences in sucrose consumption were independent of baseline running or novelty exploration. Thus, dopamine antagonism seems to have anergic rather than anhedonic effects, and the concurrent presentation in this setting could be useful for assessing preferences based on effort requirements. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.