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Impulsive choice does not predict binge-like eating in rats

Moore, Catherine F.a,b,*; Blasio, Angeloa,*; Sabino, Valentinaa; Cottone, Pietroa

doi: 10.1097/FBP.0000000000000446
SHORT REPORT

Binge eating disorder is an addiction-like disorder characterized by recurrent, excessive food consumption within discrete periods of time, and it has been linked to increased trait impulsivity. Within impulsivity components, while impulsive action was shown to predict binge-like and addictive-like eating, the role of impulsive choice is instead unknown. The goal of this study was to determine if impulsive choice predicted, or was altered by binge-like eating of a sugary, highly palatable diet. We utilized a modified adjusting delay task procedure in free-fed rats to assess impulsive choice behavior, that is. the tendency to respond for a larger, delayed reward over a lesser, immediate reward. We found that baseline impulsive choice was not a predictor of binge-like eating in 1-h sessions of palatable diet operant self-administration. Furthermore, binge-like eating of the same palatable diet had no effect on later impulsive choice behavior. Thus, our data suggest that, unlike impulsive action, impulsive choice behavior does not predict binge-like eating in rats.

aLaboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry

bGraduate Program for Neuroscience, Boston University School of Medicine, Boston, Massachusetts, USA

* Catherine F. Moore and Angelo Blasio contributed equally to the writing of this article.

Correspondence to Pietro Cottone, PhD, Laboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, 72 E Concord St, R-618, Boston, MA 02118, USA E-mail: cottone@bu.edu

Received July 7, 2018

Accepted September 26, 2018

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