SHORT REPORTSEating high fat chow, but not drinking sucrose or saccharin, enhances the development of sensitization to the locomotor effects of cocaine in adolescent female ratsSerafine, Katherine M.a; Bentley, Todd A.a; Koek, Woutera,b; France, Charles P.a,b Author Information Departments of aPharmacology bPsychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA Correspondence to Charles P. France, Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7764, San Antonio, TX 78229, USA E-mail: [email protected] Received August 3, 2014 Accepted October 20, 2014 Behavioural Pharmacology: April 2015 - Volume 26 - Issue 3 - p 321-325 doi: 10.1097/FBP.0000000000000114 Buy Metrics Abstract Eating high fat chow accelerates the development of sensitization to cocaine-induced locomotion in female rats. It is not known whether consumption of sucrose or saccharin also increases sensitivity to the behavioral effects of cocaine or whether continuous (or intermittent) access to these feeding conditions is necessary to change sensitivity. Adolescent female Sprague–Dawley rats were assigned to one of seven feeding conditions from postnatal day 25 through to postnatal day 60. The rats either ate high fat (60% kcal from fat) chow and drank water or ate standard (17% kcal from fat) chow and drank either water, a 10% sucrose solution, or a 0.1% saccharin solution. The rats either had continuous access to high fat chow, sucrose, or saccharin, or had intermittent access (i.e. 2 days/week) to these substances, with access to water and standard chow on other days. As compared with standard chow, continuous (but not intermittent) access to high fat chow enhanced the development of sensitization to cocaine-induced (1–17.8 mg/kg) locomotion; drinking sucrose or saccharin (continuous or intermittent access) did not alter the development of sensitization to cocaine-induced locomotion. The impact of feeding condition on the behavioral effects of cocaine varies between sexes and across dietary composition. Copyright © 2015 YEAR Wolters Kluwer Health, Inc. All rights reserved.