ORIGINAL ARTICLESWithdrawal from chronic exposure to amphetamine, but not nicotine, leads to an immediate and enduring deficit in motivated behavior without affecting social interaction in ratsDer-Avakian, Andre; Markou, AthinaAuthor Information Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California, USA Correspondence to Professor Athina Markou, PhD, Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, M/C 0603, La Jolla, CA 92093-0603, USA E-mail: firstname.lastname@example.org Received 4 March 2010 Accepted as revised 4 May 2010 Behavioural Pharmacology: July 2010 - Volume 21 - Issue 4 - p 359-368 doi: 10.1097/FBP.0b013e32833c7cc8 Buy Metrics Abstract Psychostimulant withdrawal leads to depressive symptoms, such as anhedonia and social dysfunction. We determined the effects of withdrawal from chronic exposure to nicotine (9 mg/kg/day salt, 28 days) or amphetamine (10 mg/kg/day salt, 7 days) on the motivated response for a sucrose reward and on social interaction in rats. Both nicotine and amphetamine exposure increased the motivated response for sucrose. However, only spontaneous amphetamine withdrawal led to an immediate and persistent decrease in motivated behavior, which was not correlated with body weight loss. Social interaction was not affected during withdrawal from either drug. These results indicate that withdrawal from chronic amphetamine exposure leads to an immediate and enduring anhedonic state. © 2010 Lippincott Williams & Wilkins, Inc.