ORIGINAL ARTICLESRasagiline improves learning and memory in young healthy ratsWong, Fong-Kuan; Lee, Sherry Hung-Wah; Atcha, Zeenat; Ong, Agnes Bee-Leng; Pemberton, Darrel John; Chen, Woei-ShinAuthor Information GSK R&D China, Singapore Research Centre, Singapore Correspondence to Dr Woei-Shin Chen, PhD, GSK R&D China, Singapore Research Centre, Biopolis at One-North, 11 Biopolis Way, The Helios Building, #03-01/02, Singapore 138667, Singapore E-mail: [email protected] Present address: John Pemberton, Neurosciences Division, Johnson and Johnson PRD, Turnhoutseweg 30, Beerse B2340, Belgium Received 3 December 2009 Accepted as revised 2 April 2010 Behavioural Pharmacology: July 2010 - Volume 21 - Issue 4 - p 278-282 doi: 10.1097/FBP.0b013e32833aec02 Buy Metrics Abstract The effect of rasagiline on learning and memory in Lister-Hooded rats was investigated in this study. Two cognitive tests were used: a 24-h temporal deficit novel object recognition test and a modified water maze task. Rasagiline (0.3 and 1 mg/kg) was administered subcutaneously 15 min before the cognitive tests. In a novel object recognition test, rasagiline treatment enhanced object recognition memory. A small effect was observed with 0.3 mg/kg rasagiline; at 1 mg/kg, rasagiline-treated animals spent twice as much time exploring the novel object. On the water maze test, the use of an on-demand platform allowed adjustment of the difficulty of this spatial learning task. This enabled the detection of a small positive effect of rasagiline (1 mg/kg) on spatial learning, which was not observed in earlier reports. For the first time, our study has showed the procognitive effect of rasagiline in young healthy rats. On the basis of these findings, a monoamine oxidase-B inhibitor would seem to be a potential symptomatic treatment for cognitive impairments affecting patients with neurodegenerative disorders. © 2010 Lippincott Williams & Wilkins, Inc.