Research PapersBupropion and sertraline enhance retrieval of recent and remote long-term memory in ratsBarros, D.M.a; Izquierdo, L.A.b; Medina, J.H.c; Izquierdo, I.bAuthor Information aDepartamento de Ciencias Fisiológicas, Fundação Universidade de Rio Grande, Rio Grande, RS, Brazil bCentro de Memoria, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil cInstituto de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina Correspondence to I. Izquierdo, Centro de Memoria, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil. E-mail: [email protected] Received 21 February 2002 accepted as revised 8 May 2002 Behavioural Pharmacology: May 2002 - Volume 13 - Issue 3 - p 215-220 Buy Abstract Wistar rats were trained in step-down inhibitory avoidance at the age of 3 months, and tested for retrieval either 1 day later or 3, 6, 9, 12, 15 or 19 months later, when the animals were 6, 9, 12, 15, 18 or 22 months old, respectively. Bupropion (20 or 60 mg/kg) and sertraline (3.3 or 10 mg/kg) given orally 6 or 3 h before retention testing, respectively, enhanced retrieval of this task at all training-test intervals, despite the fact that retrieval at the longest intervals was practically not seen in control animals. The effect cannot be explained by influences of the drugs on locomotor activity; the treatments had no effect on open field behaviour at the age of 3, 8 or 21 months. The findings may be relevant to the use of these drugs as cognitive enhancers in elderly subjects. © 2002 Lippincott Williams & Wilkins, Inc.