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Prostate Cancer: Localized: Surgical Therapy VI (MP64): Moderated Poster 64: Monday, September 13, 2021

MP64-19 PROSTATITIS AFTER BIOPSY MAY HAVE A NEGATIVE IMPACT ON BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY

Pose, Randi M.; Korten, Michael; Michl, Uwe

doi: 10.1097/JU.0000000000002104.19
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INTRODUCTION AND OBJECTIVE:

Prostatitis after biopsy potentially alters immunologic parameters in the prostate and therefore could affect PSA free survival after radical prostatectomy.

METHODS:

Patients with a biopsy and subsequent acute prostatitis three months before planned radical prostatectomy in our tertiary care centre were compared with patients who did not report prostatitis using multivariate analysis as well as propensity score matching.

RESULTS:

Of 19101 patients studied in our retrospective database, a history of prostatitis was noted in 532 patients. In 125 patients this was classified as post-biopsy prostatitis, 127 patients suffered from chronic prostatitis and in 273 patients the prostatitis could not be further classified. After 1:3 propensity score matching with patients without prostatitis, there was no significant difference in preoperative PSA, pT, pN, Gleason, and positive margin between the groups. The analysis revealed significantly worse PSA free survival in patients with post-biopsy prostatitis. In multivariable analysis of all 19101 patients, post-biopsy prostatitis was also associated with significantly worse PSA free survival.

CONCLUSIONS:

Post-biopsy prostatitis may have a negative impact on PSA free survival after radical prostatectomy. This could be related to an altered immunological defense status.

Source of Funding:

None

© 2021 by American Urological Association Education and Research, Inc.