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Pressure Ulcer Healing with a Concentrated, Fortified, Collagen Protein Hydrolysate Supplement: A Randomized Controlled Trial

Lee, S. Kwon MD, FACS; Posthauer, Mary Ellen RD, CD, LD; Dorner, Becky RD, LD; Redovian, Vicki MA, RD, LD; Maloney, Mary Jane MSN, CNP, CWS

Advances in Skin & Wound Care: March 2006 - Volume 19 - Issue 2 - p 92-96
FEATURES: ORIGINAL INVESTIGATION

OBJECTIVE: To compare Pressure Ulcer Scale for Healing (PUSH) scores at 8 weeks in long-term-care residents with pressure ulcers who were given standard care plus a concentrated, fortified, collagen protein hydrolysate supplement vs. residents who were given standard care plus placebo.

DESIGN: Randomized, prospective, controlled, multicenter trial at 23 long-term-care facilities in 4 states.

SUBJECTS: A total of 89 residents with Stage II, III, or IV pressure ulcers were entered into the trial; 71 residents completed the study.

INTERVENTION: Residents were randomized to receive standard care plus a concentrated, fortified, collagen protein hydrolysate supplement (n = 56) or standard care plus placebo (n = 33) 3 times daily for 8 weeks. Wound healing was assessed biweekly using the PUSH tool, version 3.0. This tool categorizes pressure ulcers by surface area, exudate, and type of wound tissue.

PRIMARY OUTCOME MEASURE: Change in PUSH tool scores in each group at 8 weeks.

RESULTS: After 8 weeks of treatment, residents who received standard care plus the concentrated, fortified, collagen protein hydrolysate supplement had significantly better PUSH tool scores compared with those who received standard care plus placebo (3.55 ± 4.66 vs 3.22 ± 4.11, respectively; P < .05).

CONCLUSION: By week 8, PUSH tool scores-a measurement of pressure ulcer healing-showed approximately twice the rate of pressure ulcer healing in the treatment group compared with the control group. A concentrated, fortified, collagen protein hydrolysate supplement may be of benefit to residents of long-term-care facilities who have pressure ulcers.

In this study conducted at 23 long-term-care facilities, pressure ulcer healing, as measured by scores on the Pressure Ulcer Scale for Healing, was significantly better in long-term-care residents who received standard care plus a concentrated, fortified, collagen protein hydrolysate supplement than in those who received standard care plus placebo.

S. Kwon Lee, MD, FACS, is President and CEO, Northeast Surgical Associates of Ohio, Ltd, Independence, OH. Mary Ellen Posthauer, RD, CD, LD, is a consulting registered dietitian and Regional Vice President, SupremeCare West, Inc, Evansville, IN. Becky Dorner, RD, LD, is President, Becky Dorner & Associates, Inc, Akron, OH. Vicki Redovian, MA, RD, LD, is a consultant dietitian, Nutrition Consulting Services, Inc, Akron, OH. Mary Jane Maloney, MSN, CNP, CWS, is corporate nurse practitioner, Northeast Surgical Associates of Ohio, Ltd, Independence, OH. This research was supported by Medical Nutrition USA, Inc, Englewood, NJ. Mary Ellen Posthauer, RD, CD, LD, has disclosed that she is a consultant for Medical Nutrition USA, Inc. Becky Dorner, RD, LD, has disclosed that she is a past consultant to Medical Nutrition USA, Inc.

Submitted July 11, 2005; accepted in December 14, 2005.

© 2006 Lippincott Williams & Wilkins, Inc.