Smartphone Cameras to Improve Patient Adherence and Outcomes and Curb Healthcare Expenditures
Healthy.io has announced a new digital health product: Dip.io, which uses smartphone cameras as a clinical grade diagnostic device to test for protein, glucose, and blood in urine. Regular urine testing is required for individuals with a wide range of conditions such as pregnancy, kidney disease, diabetes, high blood pressure. Dip.io is a home-based, smartphone-enabled urinalysis kit that allows patients to conduct urine testing in the privacy of their own home. Considering laboratory testing is time consuming and inconvenient, this new technology could potentially improve patient adherence and save billions of dollars in healthcare expenditures through better access and prevention through early screening for kidney disease. A study initiated by the National Kidney Foundation demonstrated significant adherence improvement based on the Healthy.io adherence-as-a-service platform compared with standard of care. Healthy.io is currently expanding its "medical selfie" portfolio to standardized assessment of chronic wounds.
PICO for Prophylactic Use in Surgically Closed Incisions to Reduce Surgical Site Complications
Complications from surgical incisions are a significant and expensive health problem contributing to significant morbidity and mortality globally. A recent World Union of Wound Healing Societies consensus guideline reports that up to 60% of surgical site infections (SSIs) are preventable. In a recent Medtech innovation briefing, the prophylactic use of the PICO system was recommended to reduce surgical site complications (SSCs), including SSIs and dehiscence of the surgical incision in patients at elevated risk. The PICO dressing has a proprietary AIRLOCK Technology that uniformly and consistently delivers negative pressure wound therapy across a surgical incision and the surrounding zone of injury generated naturally by the incision itself. The dressing is designed to help reduce the risk of wound complications by reducing postoperative fluid, swelling, and associated tension around a closed surgical incision compared with standard dressings. The effectiveness of PICO in reducing SSCs has been examined in 10 RCTs and multiple observational studies. A recently published 1,839 patient meta-analysis demonstrated the efficacy of PICO, used prophylactically, significantly reducing SSIs by 58% in closed surgical incisions compared with standard care.
Mölnlycke Acquires German Wound Care Company SastoMed GmbH
Mölnlycke has acquired German wound care products company SastoMed GmbH, bringing two new and complementary products to Mölnlycke's wound care portfolio:
- Granulox: a haemoglobin-based topical oxygen therapy spray that is sprayed on wounds to promote wound healing.
- Granudacyn: a hypochlorous wound irrigation solution for cleaning, moistening, and rinsing acute, chronic, and contaminated wounds.
Granulox won the 2018 Innovation Award at the European Wound Management Association's Congress in Krakow. Studies report that Granulox can reduce the total cost of diabetic foot ulcer treatment by around 60% a year.
Compound to Reverse Skin Changes Associated with High Dietary Intake of Fat and Cholesterol
Johns Hopkins investigators developed a new compound, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP) and used it to successfully reverse hair loss, hair whitening, and skin inflammation. The compound deters the production of certain fats called glycosphingolipids that are major components of skin and other cell membranes. High dietary intake of fat and cholesterol is responsible for hair discoloration, extensive hair loss, and inflammation of skin exhibited by multiple wounds. The research team found that mice eating a Western diet high in fat experienced an infiltration of neutrophils, a type of white blood cell implicated in inflammation, in various skin areas. Treatment with D-PDMP in a capsule significantly reduced the number of neutrophils, implying reduced skin inflammation and wounding.
Autologous Cell Harvesting Device for the Treatment of Burns
AVITA Medical announced its plans to launch RECELL Autologous Cell Harvesting Device in the treatment of burns. The RECELL Device is an investigational medical device in the U.S. that is designed to produce a Regenerative Epidermal Suspension at the point-of-care using a small sample of the patient's own skin. The autologous suspension contains cells necessary to regenerate epidermis and reduce the amount of donor-site skin. A premarket approval application for the treatment of burn injuries is currently under review by the U.S. FDA.
Nanofiber-based Wound Dressings with Vitamin D
Oregon State University researchers have developed a nanofiber-based wound dressing containing the bioactive form of vitamin D (1,25-dihydroxyvitamin D3) to induce the production of a peptide (hCAP18/LL37) that kills microbes by disrupting their membranes. Because the dressings work by enhancing innate immune responses rather than by containing conventional, single-target antimicrobial compounds, they are less likely to contribute to drug resistance. The research team used electrospinning to generate nanofiber wound dressings that are superior to hydrogels for local drug delivery.
Nexodyn AcidOxidizing Solution for Healing Chronic Wounds
APR Applied Pharma Research announces the publication in Advances in Skin & Wound Care (April 2018) of the results of a clinical pilot study on the efficacy and tolerability of Nexodyn AcidOxidizing Solution (AOS). AOS is a sprayable cleanser with that helps normalize the pH of chronic wounds and promote biochemical reactions as part of the healing process. The pilot study was conducted with a prospective, single-arm design. Thirty patients with critically colonized or locally infected chronic leg ulcers in Austria were recruited. AOS was applied on each leg ulcer at every dressing change for 35 days together with a nonadherent gauze and a multi-purpose absorbent dressing. By the end of the study period, treatment with AOS led to the full healing of 37% of the chronic wounds as well as to a significant decrease in wound size (P < .001). No adverse events were reported over the study duration, and patients reported high levels of pain relief and comfort.