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Get It Off Your Chest: A Narrative Review of Breast Ulcers

Shavit, Eran MD; Alavi, Afsaneh MD, MSc, FRCPC

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Advances in Skin & Wound Care: June 2022 - Volume 35 - Issue 6 - p 306-313
doi: 10.1097/01.ASW.0000826864.20824.b5



Cutaneous ulceration is a common cause of morbidity worldwide.1,2 Common types of skin ulcers include diabetic foot ulcers; vascular ulcers, such as chronic venous insufficiency and peripheral arterial dysfunction; and pressure injuries.3 However, depending on the underlying etiology, skin ulceration may appear in any anatomic region including the breast tissue. The authors have used anatomy as a framework to facilitate clinicians’ recall for the long list of differential diagnoses in ulcer management, previously publishing an approach to scalp ulcers.4 Breast ulcers are uncommonly encountered in medical practice but are a unique, specific anatomic location that can be affected. In contrast to the aforementioned ulcers with specific pathophysiologic backgrounds to explain their development (eg, neuropathy in diabetic foot ulcers or vascular incompetence for venous leg ulcers or arterial leg ulcers), ulceration of the breast tissue has a wide array of possible causes. Breast tissue tends to ulcerate when exposed to trauma because of the presence of fatty tissue immediately under the skin. Naturally, these ulcers are more frequently encountered in women, but the exact prevalence is difficult to determine. Nevertheless, it requires more than trauma alone to sustain ulceration of the breast.

In this review article, the authors discuss several types of breast ulcers, including trauma-induced breast ulcers; infections (mastitis); iatrogenic causes due to medications; radiation-induced ulcers; factitious ulcers; postoperative complications such as dehiscence; and inflammatory causes, including pyoderma gangrenosum (PG), granulomatous vasculitis, and ulcers resulting from neoplastic illness.5 In addition, the authors provide clinicians with guidance regarding patient management. The Table provides a list of possible differential diagnoses, their clinical features, and treatment options, and Figure 1 provides an algorithm to facilitate accurate diagnosis.

Diagnosis Category Clinical Features Treatment
Traumatic and iatrogenic breast ulcerations Various clinical presentation, localized Removal of underlying triggers, proper wound care
Radiation dermatitis Erythematous, firm, sclerotic tissue, ulceration Topical corticosteroids, emollients, proper wound care, monitor for evolvement of squamous cell carcinoma
Postoperative wound complications
 Postoperative wound infection Linear ulcers on or underneath the fatty breast tissue, surrounded by edema, erythema, local tenderness, wound bed secretions Systemic antibiotics, saline compresses, rest and analgesics, debridement of ulcer
 Postoperative wound dehiscence Linear ulcers on or underneath the fatty breast tissue, may observe previous suture site
 Mastectomy flap necrosis Necrotic (blackish) skin surrounded by sutures Surgical debridement, resection of flaps, and novel correction with new flap or leave for secondary intention
Infection Erythema, edema, local warmth, wedge-shaped area over the breast, tenderness, increased secretions in ulcer bed +/− fever or axillary lymphadenopathy Systemic antibiotics, saline compresses, rest, and analgesics
Intertrigo Localized erythema and edema underneath the breast tissue near metal underwire of bra Topical combined preparations
Inflammatory causes
 Hidradenitis suppurativa Furuncles, abscesses, and sinus tracts, scars located in the submammary areas; lesions may also be located in the axilla, groin, and inguinal areas Systemic antibiotics (rifampicin with clindamycin, doxycycline), biologics such as adalimumab (anti-TNF-α)
 Pyoderma gangrenosum Ulcer with undermining border and tenderness at ulceration site; “wrinkled paper” scar once healed Systemic corticosteroids, immunosuppressive medications (eg, mycophenolate, cyclosporin), IVIg, anti-TNF-α
 Granulomatous mastitis Firm to hard mass with overlying erythema or tumor that may involve any part of the breast, but most often is found in the upper outer quadrant Depending on the underlying etiology, antibiotics, systemic corticosteroids, immunosuppressive medications (eg, mycophenolate, cyclosporin), or surgery
Vasculitis and autoimmune diseases
 Pemphigus vulgaris Mostly erosions but lesions may ulcerate, remnants of flaccid bullae or vesicles Rituximab, systemic corticosteroids, immunosuppressive medications (eg, mycophenolate, azathioprine)
 Vasculitis Palpable purpuric papules, pustules, ulcers of various size Treat the underlying condition if possible; stop offending drug; systemic corticosteroids; immunosuppressive medications (eg, mycophenolate, azathioprine); biologics such as etanercept, infliximab, adalimumab (anti-TNF-α)
 Panniculitis of the breast Hard, firm tender nodules Treat the underlying condition if possible, antimalarial drugs, systemic corticosteroids, immunosuppressive medications (eg, mycophenolate, azathioprine), and surgery
Vascular disorders
 Diffuse dermal angiomatosis An indurated, painful erythematous plaque that later erupts as an ill-defined cutaneous ulcer Surgery
 Mondor disease A painful cord-like induration in the affected area; rarely, lesions may ulcerate Warm compresses and nonsteroidal anti-inflammatory drugs; rarely, corticosteroid injections or surgery
Neoplastic ulcers of the breast
 Adenocarcinoma of the breast Early lump without associated skin findings Surgery, radiation, chemotherapy, and hormonal therapy
 Squamous cell carcinoma Erythematous scaly patch or slightly elevated plaque that later ulcerates Surgery
 Basal cell carcinoma Shiny pearly papule with rolled border and central ulceration Surgery
 Phyllodes tumor Firm, smooth, rubbery, well-defined tumors that vary in size and mimic fibroadenomas Surgery
 Breast lymphoma Red-brown nodules or tumors Surgery, radiation, chemotherapy
 Breast fibrosarcoma Rare, poorly defined stony hard tumors Surgery, radiation, chemotherapy
Drug-induced ulcers of the breast
 Warfarin necrosis Partial retiform purpura within or at the margin of the cutaneous lesions Cessation of warfarin therapy, heparin, vitamin K, protein C
 Factitious Various clinical pictures may mimic infection or PG-like presentation Refer to a psychiatrist, cognitive behavioral therapy, SSRIs, TCAs, antipsychotic medications
 Brown recluse spider bite (rare) Indurated and erythematous and dry necrotic eschar that erupt as ulcer; may be associated with constitutional symptoms (eg, fever, fatigue) Systemic antibiotics, systemic corticosteroids, antihistamine medications, proper wound care
Abbreviations: IVIg, intravenous immunoglobulin; PG, pyoderma gangrenosum; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant; TNF-α, tumor necrosis factor α.

Figure 1:
BREAST ULCER DIAGNOSTIC ALGORITHMAbbreviations: ACTD autoimmune connective tissue disease; BU, breast ulcer; Bx, biopsy; Cx, clinical presentation; Dg, diagnosis; DIF, direct immunofluorescence assay; DM, dermatomyositis; ESRD, end-stage renal disease; FBU, factitious breast ulcer; HS, hidradenitis suppurativa; Hx, history/anamnesis; GM, granulomatous mastitis; MD, Mondor disease; NL, necrobiosis lipoidica; NXG, necrobiosis xanthogranuloma; PG, pyoderma gangrenosum; PLTCL, panniculitis-like T-cell lymphoma; RU, radiation ulcer; US, ultrasound; VAC, vacuum-assisted closure; WN, warfarin necrosis. *The five cardinal signs of inflammation are redness, swelling, heat, pain, and loss of function.

Information for this review was gathered from textbooks; PubMed, EMBASE, and MEDLINE literature searches; and expert opinion. The PubMed, EMBASE, and MEDLINE searches were performed using search words including “skin ulcers,” “skin ulcerations,” “cutaneous ulcerations of the breast,” “pyoderma gangrenosum of breast,” “hidradenitis suppurativa of the breast,” and “diffuse dermal angiomatosis of the breast,” together with additional key words such as “malignant ulcers of the breast,” and “nonhealing ulcers of the breast.”


Postoperative Wound Complications

Slow-healing wounds may appear after breast surgery as a result of wound infection, necrosis of mastectomy flaps, and wound dehiscence.6 The latter is one of the most prevalent noninfectious wound complications after mastectomy. Unless there is an underlying specific cause to prevent or stall wounds from healing, such as diabetes mellitus, morbid obesity, smoking, or immunosuppressive illness or medications, postoperative wounds are considered healable ulcers. Such cases should be evaluated individually to determine the reasons for the eruption of wounds and/or stalled healing process and, if necessary, may be referred to a wound healing clinic for further management.

Traumatic and Iatrogenic Breast Ulcerations

Breast tissue may be subject to trauma due to motor vehicle crash or any other source of damage to the skin, such as penetrating injury. Cutaneous necrosis of the breast tissue may also be iatrogenically caused by radiation injury that erupts as open wounds many years later, adverse reactions to implants or other injections, or self-inflicted manipulation of the tissue. A thorough medical history is critical in the diagnosis of these conditions.

Infection-Induced Breast Ulcerations

In conjunction with localized fungal and bacterial infection, local trauma, such as that provoked by the metal underwire of a bra, may lead to erythema and edema in certain cases; this is termed intertrigo. If left untreated, this may eventually ulcerate (Figure 2). Initial treatment for intertrigo includes commercially available topical creams including corticosteroids, antifungals, and antibacterial preparations. In selected cases, systemic antibacterial or antifungal medications are required. Viral infection with herpes zoster (varicella-zoster virus) is relatively common in older adults and can be treated with systemic acyclovir or valacyclovir. It rarely ulcerates, but this diagnosis must be considered.

Figure 2:
BREAST ULCERS INDUCED BY INTERTRIGO AND LOCALIZED INFECTIONPatient provided consent for image to be published.

Radiation Dermatitis

Traditionally, radiotherapy was one of the core therapies involved in breast cancer management regimens; however, the by-product of radiotherapy was collateral damage to the surrounding skin, including dermatitis and ulceration.7 With the introduction of new technologies in radiation therapy, fewer radiation-induced cutaneous lesions are observed. Most currently affected patients are older adults who were treated with radiation decades ago for breast carcinoma. Common cutaneous reactions include erythema, edema, peeling, pigmentary changes, and, less often, ulceration. When chronic radiation-induced ulcers in the chest wall do occur, they are difficult to heal because of the reduced blood supply, fibrosis, and impaired cellular repair potential associated with radiation therapy.7,8 The ulcers may enlarge and deteriorate if left untreated.9

Oil-based breast implants are out of favor in almost all countries and have been replaced by newer types of implants, including silicone. However, there are multiple case reports of breast ulcerations years after implant surgery, and foreign body granuloma formations due to implant rupture.10,11

Factitious Ulcers

Physically induced lesions may appear after self-manipulation, as published in one case report of a 22-year-old patient with unusual ulcers that were diagnosed histologically as lobular panniculitis. After meticulous anamnesis and tighter surveillance, the patient confessed to self-inflicting trauma to introduce the lesions. Because factitious ulcers are extremely rare, they are a diagnosis of exclusion after a thorough history and extensive survey appear futile. Only then should the clinician reinvestigate the patient. Establishing a rapport based on trust will put the patient at ease to admit the etiology.12 Factitious ulcer misdiagnosis can lead to repetitive biopsies, unnecessary surgeries, poorer outcomes, and patient dissatisfaction.

Brown Recluse Spider Bite

Brown recluse spiders, endemic to some parts of the world, such as the southern part of the US, are notorious for inducing cutaneous necrosis when accidentally encountering human beings. The affected skin appears indurated, and erythematous and dry necrotic eschar may appear approximately 7 to 10 days after the bite of the spider. Most often their bite is followed by a relatively benign course, but rarely it may cause significant tissue injury associated with constitutional symptoms termed loxoscelism, hemolytic anemia, and even death.13 The most affected areas include the buttocks, thighs, and shins and only rarely the breast tissue.14

Inflammatory Disease of the Breast

Pyoderma Gangrenosum

This uncommon, ulcerative cutaneous disease has a unique morphologic presentation. It belongs to the neutrophilic dermatoses group and is frequently associated other systemic diseases, including inflammatory bowel disease, rheumatoid arthritis, and hematologic malignancy.15,16 Although PG may affect any anatomic location, it most commonly presents on the limbs, especially the lower extremity, around an abdominal stoma, or adjacent to wounds including postsurgical sites.17,18 Although the breast is not a common location for PG lesions, it is a common surgical site, and postsurgical PG is a common complication of breast and chest surgeries. The diagnosis of PG relies mainly on clinical background, usually with an underlying etiology suggestive of the disease. Because the histopathology of PG is nonspecific, it is a diagnosis of exclusion. However, recently, the diagnosis of ulcerative PG has been revised to include one major histopathologic criterion (neutrophilic infiltrate) and four out of eight minor criteria to fulfill the requirements to establish the diagnosis of ulcerative PG.19 Reports indicate that PG presenting on the breast usually does not involve the nipple, which could be related to different skin structures and cell types.19–22 It is important to counsel patients with a history of PG or high risk for PG regarding pathergy (induction of PG lesions after trauma), so they are aware of the risk of ulceration following any elective procedure such as breast piercing or future surgeries.

Autoimmune Disease of the Breast

Vasculitic Breast Ulcers

Breast ulcers have been reported in association with systemic vasculitis and mainly with granulomatosis with polyangiitis, giant cell arteritis, and polyarteritis nodosa. One literature review of 67 biopsy-proven cases reported that the typical manifestation was breast mass (79%) or breast ulcer. Glucocorticoids and immunosuppressants are the main therapies, and the prognosis is usually good.23 The clinical picture of these painful ulcers is very similar to PG, but the histology of vasculitis and laboratory tests help differentiate these conditions.

Vascular Disorders of the Breast

Diffuse Dermal Angiomatosis

Initially described by Krell et al24 as a specific subtype of reactive angioendotheliomatoses, diffuse dermal angiomatosis (DDA) is a rare, acquired entity that is related to ischemia. It is more accurately categorized as a variant of a larger group of skin diffuse vascular lesions termed cutaneous reactive angiomatosis.25 There are three major subtypes of DDA: intravascular reactive angioendotheliomatoses, diffuse reactive angioendotheliomatoses, and acroangiodermatitis. Diffuse dermal angiomatosis was originally described as a variant of cutaneous reactive angioendotheliomatoses, which is characterized by hyperplasia of endothelial dermal cells and intravascular proliferation. However, DDA is now more commonly considered to be a distinct disorder on the spectrum of cutaneous reactive angioendotheliomatoses rather than as a variant of this group of disorders. Although DDA may be located anywhere, it primarily presents on the limbs; vascular ischemia is related to its underlying cause. Although breast tissue is not a commonly affected area, approximately 15 case reports of DDA affecting the breast have been published. Because the underlying etiology may be vascular, patients with peripheral vascular diseases and its risk factors, such as smoking and diabetes mellitus, are at greater risk.

The morphologic presentation of DDA varies but generally is depicted as an indurated and painful erythematous plaque that spontaneously erupts as an ill-defined cutaneous ulcer. The histopathologic findings include a proliferative endothelial lesion involving the reticular dermis. The lesion contains compactly arranged cells without atypia or mitosis-forming, variably sized luminal structures dissecting between dermal collagen bundles. Mixed minimal inflammatory cell infiltrate is present, and scattered intraluminal thrombi may be present as well.26 The morphologic presentation is not specific and may vary; hence, the diagnosis relies on the histopathologic background. The treatment is surgical correction. Recurrence is uncommon.26,27 Although DDA is benign, it may be alarming clinically and may end with cutaneous ulceration.27

Mondor Disease

Mondor disease is superficial thrombophlebitis of the breast, an uncommon and self-limiting disease that only rarely causes ulceration. Risk factors include smoking, pendulous breasts, and peripheral vascular disease. However, because of the various causes that may lead to this condition, including breast surgery, it should be mentioned here.28 Inciting events that may cause Mondor disease include breast biopsy; surgery, including breast augmentation procedures, even many years after the procedure was performed;29 breast carcinoma; and trauma. Morphologically, a painful cord-like induration may appear in the affected area, corresponding to the involved vein. Rarely, these lesions may ulcerate.30 The clinical diagnosis is confirmed with Doppler ultrasonography. Although self-limiting, patients with Mondor disease are treated with warm compresses and nonsteroidal anti-inflammatory drugs. Rarely, other invasive measures such as corticosteroid injections or surgery may be warranted.28


Neoplastic Ulcers of the Breast

Ulcerated Breast Cancer

The anterior chest wall and breast are the most common location for cutaneous metastasis due to direct extension of cancer; breast cancer is the most common primary cancer-causing cutaneous metastasis.31 Ulcerated breast cancer represents a subgroup of locally advanced breast cancer with an unfavorable tumor stage and poor overall survival.32,33 Fortunately, this group does not represent most breast cancers (approximately 6% to 15%). In one study evaluating the histopathologic features of ulcerated versus nonulcerated breast cancers, most of the neoplasms were invasive ductal carcinoma (85.5%), and only 9.9% were noninvasive ductal carcinoma.33 Yet, cancers with much less frequent primary breast neoplasm, such as sarcoma, may present as ulcerated lesions as well, requiring tissue biopsy.34 Other general characteristics of ulcerated breast neoplasm observed in previous research include advanced age at diagnosis, larger tumor size, and greater lymph node involvement.33–35

Nonmelanoma Skin Cancer

Squamous cell carcinoma and basal cell carcinoma are nonmelanoma neoplasms most commonly affecting sun-exposed areas in the head and neck region.36 These lesions may present clinically as localized ulcerated lesions that are usually amenable to surgical therapy. Breast tissue is not common for such presentation but should still be sought in the differential diagnosis.37

Phyllodes Tumors

Phyllodes tumors of the breast are rare, rapidly growing tumors that mimic fibroadenomas; they account for less than 1% of all breast tumors.38,39 Phyllodes tumors may be benign or malignant and are usually encountered in women in their fourth decade of life. Accurate diagnosis requires histopathologic sampling; if the tumor is malignant, complete surgical excision is required.40 Other tumors such as lymphoma are extremely rare but may occur and are provided in the algorithm (Figure 1).

Inflammatory Disease of the Breast

Hidradenitis Suppurativa

A chronic cutaneous disease of the folliculoinfundibular unit, hidradenitis suppurativa (HS) is characterized clinically with the eruption of furuncles, abscesses, and sinus tracts that heal with scars and occurs most often in the axilla, groin, and inguinal areas.41 The breast tissue, especially the submammary areas, are also known affected areas.42 Diagnosis is made on clinical grounds, and histopathologic sampling is rarely required. Although sinus tracts or fistulous tracts are the cutaneous features of HS, when lesions erupt and are left untreated, they may appear as ulceration (Figure 3). Further, HS may rarely be associated with PG in syndromic disorders such as PASH (PG, acne, and suppurative hidradenitis).43 Treatment is established based on staging and may involve local and/or systemic antibiotics, anti-inflammatory drugs, and immunomodulatory drugs. However, when HS is located on the breast, proper wound management cannot be overemphasized.42,44

Figure 3:
A 50-YEAR-OLD PATIENT WITH HIDRADENITIS SUPPURATIVAPatient has a submammary ulcer as well as other lesions typical of hidradenitis suppurativa. Patient provided consent for image to be published.

Granulomatous Mastitis

Idiopathic granulomatous mastitis is a rare, benign, chronic inflammatory condition of the breast involving young women. The histology is consistent with noncaseating granuloma with or without abscess formation.45 It usually imposes diagnostic challenges, and exclusion of other conditions such as sarcoidosis, granulomatous vasculitis, and infectious causes is needed in most cases.

The most common presentation of granulomatous mastitis is a subcutaneous mass with overlying erythema in any quadrant, but most often in the upper outer quadrant.45,46 The mass can be painful and often has a cutaneous peau d’orange appearance, abscess, draining tunnels, and, uncommonly, ulcerations. The diagnosis requires a high index of suspicion with a histology to exclude other causes. Treatment options include corticosteroids, antibiotics, immunosuppressive agents, and surgery.47

Autoimmune Disease of the Breast


Inflammation of fatty tissue—panniculitis—is a rare etiology of breast ulcer but should be included in differential diagnoses because of the considerable amount of adipose tissue in the breast. Depending on the etiology, panniculitis can be classified into two main groups: suppurative and nonsuppurative. Lupus mastitis is a rare manifestation of lupus panniculitis first described in 1971. It sometimes is the initial presentation of lupus and can be associated with fat necrosis and ulceration.48 Because it can mimic breast malignancy, this brings a diagnostic dilemma requiring further investigation and histopathology. Treatment for lupus mastitis includes antimalarial drugs, systemic corticosteroids, and other immunosuppressive medications.49

Drug-Induced Ulcers

Warfarin-Induced Necrosis

Warfarin-induced skin necrosis is a rare complication of anticoagulant therapy, which commonly presents 3 to 5 days after initiation. Although not limited to the breast tissue, cutaneous necrosis may invariably involve the breast tissue. The diagnosis relies on clinical history and cutaneous features in conjunction with laboratory and histopathologic findings.50


Diagnosis requires a thorough medical history and physical examination, and, in almost all cases, histopathology sampling is mandatory as well. It provides the clinician with a primary diagnosis (eg, tumor) and aids in ruling out other pathologic possibilities. For example, a pathologist may easily discern tumors such as adenocarcinoma with hematoxylin-eosin staining, even without the need for additional immunohistostaining to support the diagnosis. In contrast, inflammatory disorders may require clinicopathologic correlation for the suggested clinical diagnosis. The classic histologic presentation of PG, for example, is neutrophil-rich cell infiltrate in the dermis, but this is mostly seen when an early lesion is biopsied. As emphasized previously, neoplasm must be ruled out in many cases, which is possible with the current histopathologic tools. Imaging is also essential prior to surgical intervention; this may include ultrasonography, mammography, and MRI.


The ultimate goal is to treat the underlying disease that led to the ulceration. This goal is not always feasible, though, such as in cases of advanced cancer when treatment options are limited. In these cases, palliative surgery or radiotherapy is possible, and pain management is essential. In autoimmune diseases and vasculitis, among others (Table), the core therapy is systemic corticosteroids and immunosuppressive medications.

Proper wound care includes cleansing to prevent secondary infections, the appropriate utilization of topical antibacterial agents in the presence of localized infection, and maintenance of a moist wound environment. Conservative debridement (enzymatic, autolytic, or surgical) to remove nonviable tissue should be performed while awaiting surgical correction. Proper wound healing is important when the disease is curable but is vital even if it is for palliation alone. Wound dressings should be chosen to provide comfort, control drainage, and reduce pain.


Breast ulceration results from a diverse, heterogeneous group of diseases with a shared clinical diagnosis of wounds located in the fatty breast tissue. Possible causes discussed here include infectious, inflammatory, and neoplastic disorders affecting the breast. Assessing the possible underlying etiologies will enable clinicians to approach skin ulceration of the breast systematically, facilitating accurate diagnosis and thus more quickly establishing and managing care for these patients. Appropriate care management requires a multiprofessional approach to treat the underlying disease, optimize local wound care, and manage pain.


  • A diverse group of diseases affecting the breast can induce breast ulceration.
  • Breast ulcers arise for many reasons including infection, inflammation, traumatic injury, and neoplastic illness.
  • Thorough clinical history is essential to establish the exact diagnosis; histopathologic sampling is warranted in the majority of cases.
  • Treatment is dictated by the underlying disorders but should also address other needs of the patients, including optimal wound dressing and pain management.


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breast angiomatosis; breast neoplasm; breast ulcers; breast wounds; pyoderma gangrenosum; postoperative ulcers

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