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Direct Thrombolytic Therapy for Thrombosis of a Centrifugal Flow Left Ventricular Assist Device

Jabbar, Ali Abdul*†; Yau, Raymond; Frazier, O. H.; Delgado, Reynolds III*

doi: 10.1097/MAT.0b013e3182a39628
Case Reports

In patients receiving left ventricular assistance for end-stage heart failure, pump-related thrombosis is a potentially fatal complication that may manifest as hemolysis and abnormally high pump power consumption. The optimal approach to treat this complication is unclear, especially in patients who are not heart transplant candidates or who have a high surgical risk. We report the successful use of direct thrombolytic therapy for recurrent hemolysis and thrombosis-related pump failure in a patient with the HeartWare ventricular assist device (HVAD), a third-generation, centrifugal flow pump. We know of only one previous case in which direct thrombolytic therapy has been used to treat the failure of a third-generation device. On the basis of our experience in the present case, we believe that direct thrombolytic therapy is a feasible option in these patients.

From the *Department of Cardiology, Texas Heart Institute at St. Luke’s Episcopal Hospital, Houston, Texas; Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, Texas; and Department of Cardiovascular Surgery, Texas Heart Institute at St. Luke’s Episcopal Hospital, Houston, Texas.

Submitted for consideration November 2012; accepted for publication in revised form February 2013.

Disclosures: The authors have no conflicts of interest to report.

Reprint Requests: Reynolds Delgado, MD, Department of Cardiology, Texas Heart Institute, 6624 Fannin, Suite 2420, Houston, TX 77030. Email:

Copyright © 2013 by the American Society for Artificial Internal Organs