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June 2023

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Single-site veno-pulmonary arterial (V-PA) ECMO through dual-lumen right atrium (RA) topulmonary artery (PA) cannula (left panel), and dual-site V-PA ECMO through femoral vein-to-PAcannulation (right panel). IVC, inferior vena cava; LA, left atrium; LV, left ventricle; ML, membrane lung;RA, right atrium; RFV, right femoral vein; RIJV, right internal jugular vein; RV, right ventricle; SVC,superior vena cava; ECMO, extracorporeal membrane oxygenation. See Zochios V et al, Veno-Pulmonary Arterial Extracorporeal Membrane Oxygenation in Severe Acute Respiratory Distress Syndrome: Should We Consider Mechanical Support of the Pulmonary Circulation From the Outset?​

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May 2023

• Table of Contents

The MarioHeart in-vitro flow model showing mechanical heart valve and a hollow torus (top), valve chamber front view (left bottom), and side view (right bottom). See Devos et al, MarioHeart: Novel In-Vitro Flow Model for Testing Heart Valve Prostheses and Anticoagulant Therapies​


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April 2023

• Table of Contents

PET scan showing diffuse increased fluorodeoxyglucose avid uptake around the entire outflow graft of the Heartmate 3 device consistent with device infection. See Jenkins et al, ​Desperate Times Call for Desperate Measures: Bridging to Transplant in the Face of Central Device Infection​




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March 2023

• Table of Contents

Novel technique for left ventricular assist device deactivation. See Pereira AB et al, A Novel Percutaneous Technique for Left Ventricular Assist Device Deactivation Using a Left Atrial Appendage Occluder in the Outflow Cannula



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February 2023

• Table of Contents

Components of intra-abdominal forces impacting kidney perfusion during surgicalpneumoperitoneum formation. See Kopitko C et al​, Pneumoperitoneum and Acute Kidney Injury—An Integrative Clinical Concept Review


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 January 2023

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 A typical left ventricular assist device implantation: apical and outflow sensors. See Bonde P et al, Resonantly Coupled High-Efficiency Sensors for Assessment of Ventricular Chamber Size for Autonomous Control of Left Ventricular Assist Device​



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 December 2022

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Acrylic model of the implantable Penn State Fontan Circulation Assist Device. SVC, superior vena cava; PAs, pulmonary arteries; IVC, inferior vena cava. See Good BC et al, Computational Modeling of the Penn State Fontan Circulation Assist Device



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 November 2022

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Echocardiogram demonstrating hypertrabeculated LV (arrows) with normal dimensions in the (left) apical and (right)
parasternal long axis views. LV internal dimension in diastole (LVIDd) was 2.58cm, which is a Z-score of -0.3. LA=left atrium, LV=left ventricle, RA=right atrium, RV=right ventricle. See Magnetta DA et al, Biventricular Assist De​vice Support for Intractable Arrhythmias From Histiocytoid Cardiomyopathy​​


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 October 2022

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On the cover: Test samples and perfused aneurysm model chamber for thrombosis generation study. Patented “Kardiozis” fibers sewn on their outer surface (left panel) or fibered detachable coils (middle panel). Aneurysm model chambers (right panel) are 50 ml poly(methyl methacrylate) chambers with a removable mandrel for sample holding, and luer-lock compatible sockets for blood filling and perfusion. See Chaput O et al, In-vitro Assessments of Clot Elicitation by Thrombogenic Fibers vs. Embolization Coils​




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 September 2022

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The main circuit representing the simulated organism had a blood flow of 5 L/min and created a hypoxic and hypercapnic (venous) environment with N2 and CO2 as sweep gases. See Schwärzel LS et al, Preclinical Evaluation of a New ECCO2R Setup​



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 August 2022

• Table of Contents

Schematic drawing of the MobyBox device: Working principle of the pneumatic pump including the blood flow. The left and right side are illustrating the opposite positions of the chamber. See Kau M et al, First Use of a New Extracorporeal Membrane Oxygenation System in COVID19-Associated Adult Respiratory Distress Syndrome: The MobyBox Device


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 July 2022

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Porcine lungs during ex vivo lung perfusion (EVLP). Representative images of the porcine lungs after EVLP with normal saline (left panel), modified cell culture media (middle panel), and Steen® perfusates (right panel). See Peterson DM et al, Electrical Impedance as a Noninvasive Metric of Quality in Allografts Undergoing Normothermic Ex Vivo Lung Perfusion​​​​



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 April 2022

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Example case of preoperative vector flow mapping analysis by epiaortic echocardiogram. Red arrow indicates wall shear stress (WSS) on the ascending aorta. White arrow indicates WSS on the aortic root. Upper row: Vector flow mapping analysis with color Doppler. Lower row: The flow streamline and the wall shear stress. See Kainuma A et al, Left Ventricular Assist Device Support-Induced Alteration of Mechanical Stress on Aortic Valve and Aortic Wall​​​



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 March 2022

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Right ventricular global longitudinal strain measured in the 4-chamber view on a patient who developed post-left ventricular assist device (LVAD) early right heart failure (RHF) (left panel) versus a patient who did not develop post-LVAD early RHF (right panel). See Liang LW et al, Right Ventricular Global Longitudinal Strain as a Predictor of Acute and Early Right Heart Failure Post Left Ventricular Assist Device Implantation



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 February 2022

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Veno-venous extracorporeal membrane oxygenation recirculation. See Gajkowski EF et al, ELSO Guidelines for Adult and Pediatric Extracorporeal Membrane Oxygenation Circuits



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 January 2022

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Test bench featuring a steerable ultrasound beam integrated in a placeholder left ventricular assist device cannula. The authors acknowledge Jan Zimmermann for the original creation of the figure. See Dual S et al, Does Size Matter for Female Continuous-flow LVAD Recipients? A Translational Approach to a Decade Long Question​



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 December 2021

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A cannula encompassing four electrodes (B1-B4) implanted in the left ventricle mimicking the implantation of a ventricular assist device (left panel) and intra-cavity view of the cannula showing the shielded and unshielded electrodes (right panel). See Schmid Daners M et al, Real-Time Ventricular Volume Measured Using the Intracardiac Electromyogram​



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 November 2021

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Model of the miniaturized right heart replacement continuous flow pump design (left) and photographs of the post-necropsy pump teardown showing the superior vena cava (upper right) and inferior vena cava (lower right) inlets for Implant 003 (Inset: rotor after rinsing). See Cysyk J et al, Miniaturized Fontan Circulation Assist Device: Chronic In Vivo Evaluation


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 October 2021

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The Aeson Autoregulated Bioprosthetic Artificial Heart. See Netuka I et al, First Clinical Experience With the Pressure Sensor–Based Autoregulation of Blood Flow in an Artificial Heart




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 September 2021

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Pre-operative chest x-ray (left panel) and post-operative chest x-ray (right panel) for Patient 1. See Spinner J et al, “Compassionate" Cases of the Jarvik 2015 Ventricular Assist Device


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 August 2021

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Velocity streamlines in atrial diastole and systole at high circuit flow (4L/min). See Conrad and Wang, Evaluation of Recirculation During Venovenous Extracorporeal Membrane Oxygenation Using Computational Fluid Dynamics Incorporating Fluid-Structure Interaction​



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 July 2021

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Ventricular assist devices that were incorporated in the model (upper panels) and noncontinuous operation modes of HM3 (artificial pulse) and HVAD (Lavare cycle) (lower panels). Images used with the permission of Abbott and Medtronic. See Grinstein J et al, Left Ventricular Assist Device Flow Pattern Analysis Using a Novel Model Incorporating Left Ventricular Pulsatility​




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 June 2021

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Cross-sectional view of 3D physiologically representative aortic stenosis (AS) models for mild, moderate, and severe AS (left panels) (unit: cm); and a representative computational fluid dynamics geometry of moderate AS (right panel). See Jhun C-S J et al, Dynamics of Blood Flows in Aortic Stenosis: Mild, Moderate, and Severe​



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 May 2021

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Increased apical peak velocities caused by HVAD pump speed modulations (Lavare cycle), independent of timing (top) and local velocity increases compared to constant speed mode (bottom). See Khienwad et al, Effect of Timings of the Lavare Cycle on the Ventricular Washout in an In Vitro Flow Visualization Setup​



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 April 2021

• Table of Contents

COVID-19 respiratory disease before extracorporeal membrane oxygenation (ECMO) installation. 3D-reconstructed computed tomography (CT) scan. See Loforte A et al, Extracorporeal Membrane Oxygenation for COVID-19 Respiratory Distress Syndrome: An Italian Society for Cardiac Surgery Report​



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 March 2021

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Distribution of extracorporeal membrane oxygenation (ECMO) versus failing-heart blood flow within the aorta is shown as simulated during peak systole. Four different scenarios are shown which represent varying degrees of stably supported heart failure with ECMO-supplied perfusion expressed as a percentage of a total perfusion of 5 LPM. See Nezami FR et al, A Computational Fluid Dynamics Study of the Extracorporeal Membrane Oxygenation-Failing Heart Circulation



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 February 2021

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Changes in ventricular size and shape for a representative patient are shown prior to (PRE) and 1 month following (POST) left ventricular assist device (LVAD) therapy. For the left ventricle (LV), pre-LVAD endocardial surfaces are shown as clear net, and post-LVAD endocardial surfaces are shown in green. For the right ventricle (RV), pre-LVAD endocardial surfaces are shown in red, and post-LVAD endocardial surfaces are shown as a clear net. See Sayer GT et al, Short-Term Ventricular Structural Changes Following Left Ventricular Assist Device Implantation​



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 January 2021

• Table of Contents

Residence time maps at peak R-wave after 5 seconds of integration for left ventricular assist device case (left panel), a dilated cardiomyopathy case (middle panel), and a healthy control case (right panel). Black arrows indicate the velocity instantaneous magnitude and direction. See Rossini et al , doi: 10.1097/MAT.0000000000001158​​



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 November-December 2020

• Table of Contents

Femoro-internal jugular configuration for venovenous extracorporeal membrane oxygenation with a large multi-stage drainage cannula inserted in the femoral vein and a shorter, smaller single-stage return cannula inserted the internal jugular vein to be advanced at the junction between the superior vena cava and the right atrium (left panel). Bifemoral-internal jugular configuration with two multi-stage drainage cannula in the femoral veins may be necessary in case of insufficient drainage by a single cannula (middle panel). Femoro-femoral configuration for both drainage and return can be performed in absence of jugular venous access (right panel). See Guihaire et al, doi: 10.1097/MAT.0000000000001251​


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 September-October 2020

• Table of Contents

Two-dimensional biplane echocardiography images of thinned hearts before and after thinning. Left panel shows echo of hearts before thinning; right panel shows echo of hearts after thinning with mitral valve tethering. See Agra et al, doi10.1097/MAT.0000000000001145



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 August 2020

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Design of the initial Biologically inspired, Open, Helicoid (BiO-H) impeller design to optimize the pump performance. See Park et al, doi: 10.1097/MAT.0000000000001090


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 July 2020

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Appearance of Impella 5.5 on chest x-ray (left panel); Impella 5.5 in final position by Echo (top right panel); and the Impella 5.5 with SmartAssist Automatic Impella Controller (AIC) (bottom right panel). See Ramzy et al, 10.1097/MAT.0000000000001194




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 June 2020

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Breakdown of an oxygenator design for gas transfer simulations. See Kaesler et al, 10.1097/MAT.0000000000001098


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 May 2020

• Table of Contents

Flow paths in the proposed design for an artificial lung with recirculation (left panel) and in the in vitro tested prototype (right panel) are shown using red arrows. See Madhani et al,  10.1097/MAT.0000000000001030



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 April 2020

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An isometric view (left panel) and the velocity profile through the mid-plane (right panel) of the Pediatric MLung being developed at the University of Michigan Extracorporeal Life Support Lab. See Thompson et al, DOI: 10.1097/MAT.0000000000001018


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 March 2020

• Table of Contents

Intraoperative image demonstrating final positioning the sewing rings prior to pump attachment (left panel) and post-operative x-ray of pump positioning (right panel). See Daneshmand et al, 10.1097/MAT.0000000000001011




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 February 2020

• Table of Contents

Axial computed tomography (CT) images showing Total Artificial Heart (TAH) ejection (left) and filling (right) as well as the mild chest deformity due to the device. See Beasley et al10.1097/MAT.0000000000000968




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 January 2020

• Table of Contents

Illustration of Original Donor Heart from Heterotopic Heart Transplant and the Total Artificial Heart. Illustration by Dr. Ismael Salas de Armas. Design by Dr. Igor Gregoric. See Gregoric et al, 10.1097/MAT.0000000000000962 




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 November/December 2019

• Table of Contents

Simulator construction. Schematic drawing of the assembly of the simulator (left panel); photograph showing the working simulator (right panel). Abbreviations: AP: Arterial pressure; CVP: Central venous pressure; LVAD: Left ventricular assist device; PAP: Pulmonary arterial pressure; PVP: Pulmonary venous pressure; RVAD: Right ventricular assist device; VAD: Ventricular assist device. See Gehron et al, 10.1097/MAT.0000000000000880



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 September/October 2019

• Table of Contents

Right Ventricle (RV) patch function assessed by MRI strain. Diagram of a reconstructed RV endocardium showing circumferential strain analysis planes (left panel). Representative late gadolinium enhancement (LGE) image of the right ventricular outflow tract (RVOT) showing systolic bulging of the extracellular matrix (ECM);  red box shows patched region at 3 months (right panel). See Baker et al, 10.1097/MAT.0000000000000864




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August 2019

• Table of Contents

Sagittal view from a computed tomography angiography of the thorax revealing a partially occlusive thrombus impinging on the distal portion of the outflow graft. See Alnabelsi T et al, 

DOI: 10.1097/MAT.0000000000000929



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July 2019

• Table of Contents

Critical steps for transforming a current lung assist device (iLA) to a long-term ambulatory lung assist device (i-lung). Wearability can be achieved by miniaturization of all relevant hardware and disposable components. See Novosel et al 

DOI: 10.1097/MAT.0000000000000841



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May-June2019

• Table of Contents

Cannula tip design with integrated conductance catheter. Solid Works drawing of the outer shell with 4 platinum iridium electrodes (left panel) and the finished assembly (right panel). See Cysyk J et al, 

DOI: 10.1097/MAT.0000000000000818



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March-April 2019

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Diagram of the Hemopump™ system, comprised of a disposable catheter mounted pump assembly. See the Moment in History article by Wampler and Frazier.

DOI: 10.1097/MAT.0000000000000802



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February 2019

• Table of Contents

A region of interest (ROI) positioned within the LVAD inflow cannula. Beginning in diastole, ROI velocity increases during filling, and attenuates during systole. The velocity decreases from the standard cannula (left panel) to the angled orientation (right panel) for both LVAD. See May-Newman et al,   DOI: 10.1097/MAT.0000000000000790


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January 2019

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Real-time simulation of cardiovascular physiology is a promising clinical decision support tool in mechanical circulatory support and complex interventional cardiology. Figure illustrates effects of VA-ECMO 4 L/min in severe left heart failure with preserved right heart function in model Aplysia CardioVascular Lab. Severe dilatation of the left ventricle raises questions about optimal adjunct unloading interventions. See Donker DW et al, 10.1097/MAT.0000000000000755


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November/December 2018

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Gated CT image of LVAD (Heart Mate II) demonstrating normal cannula position and angle in the left ventricle as well as demonstrating a cross section of the motor (left panel). Thrombus present (indicated by the arrow) in the outflow graft confirmed at surgical explant (right panel). See Chrysant GS et al, 10.1097/MAT.0000000000000770


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September/October 2018

• Table of Contents

Isolation of adult rat cardiomyocytes (CMs). From left to right, the figure demonstrates a rat heart that was mounted above the aortic valves, the cross-section of a successfully digested heart, the representative image of indirect plating with cultured CMs, and the representative image of direct plating with fresh CMs. See Tao Z et al, 10.1097/MAT.0000000000000765​


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July/August 2018

• Table of Contents

Assembled patient specific implant form connected to the pneumatic tubes (left panel); circumferential expansion, while the implant was ascending around the beating heart, was controlled via fluoroscopy (right two panels). See Jagschies L et al, 10.1097/MAT.0000000000000686​

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May/June 2018

• Table of Contents

Chest X-ray with Right Atrial-HVAD and Left Ventricular-HVAD (left panel); and computated tomography with Right Atrial-HVAD and outflow (blue) graft, Left Ventricular-HVAD and outflow (red) graft (right panel). See Tran HA et al,  10.1097/MAT.0000000000000645​


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March/April 2018

• Table of Contents

Partial cavopulmonary connection was created by using Expanded Polytetrafluoroethylene conduit between the Superior Vena Cava and Main pulmonary artery, and application of snares on both vessels. See Sinha P et al, doi: 10.1097/MAT.0000000000000613



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January/February 2018

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Confirmation of severe stenosis of the outflow graft (right) and stenosis close to the anastomosis with the subclavian-artery (left). See Wiedemann D et al, doi: doi: 10.1097/MAT.0000000000000547

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November/December 2017

• Table of Contents

Esperanza (middle) at the 1996 ELSO meeting with Ted Kolobow (right) and Bob Bartlett (left). Esperanza was the first successful neonatal ECMO patient in 1975. See Bartlett R, doi: 10.1097/MAT.0000000000000697 ​​


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September/October 2017

• Table of Contents

Illustration of the heart with all implanted cannulas and sensors (left panel). 3D-printed LVAD inlet cannula with integrated sensors (right panel). 

See Ochsner G et al, doi: 10.1097/MAT.0000000000000533​​



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July/August 2017

• Table of Contents

The LVAD pump is exposed through a subxiphoid incision (left panel). Intraoperative views during the less-invasive LVAD exchange are shown (right panels). See Tchantchaleishvili et al, 10.1097/MAT.0000000000000502​


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May/June 2017

• Table of Contents

SLA-BRECS (left panel) consisting of top and bottom housing pieces, and a silicone gasket to make a liquid tight seal when the two pieces are assembled with an external clamp force exerted by a clamp ring (not shown). Porous disk columns from a SLA BRECS (right panels) consisting of 5, 2.5mm thick disks (20 disks); 6, 2mm thick disks (24 disks); and 8, 2mm thick disks (32 disks). Alternative disk arrangements are not shown at the same scale. See Pino et al10.1097/MAT.0000000000000485​


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March/April 2017

• Table of Contents

Schematic representation of the MiMa working principle. The balloon is inserted in the connecting line and advanced until the P2 segment (upper panels). The balloon is then inflated causing permanent deformation of the ring in the P2 area (lower panel). After the procedure, the balloon is retrieved. See Tozzi P et al, doi: 10.1097/MAT.0000000000000480​

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January/February 2017

Computed tomography angiogram (CTA) of 

a thrombus in the LVAD outflow graft (left 

panel) and the control CTA 4 days later with 

the graft outflow graft showing a sufficient 

lumen (right panel). See Hubbert et al, DOI: ​10.1097/MAT.0000000000000371​.

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November/December 2016

Preoperative chest CT-scan (left panel) with quantification of the emphysematous zones (right panel) of case 3. The blue zones 

represent the areas with maximal emphysematous destruction. 

See Redwan B et al, DOI: ​10.1097/MAT.0000000000000421​.

September/October 2016

• Table of Contents

Membrane oxygenator, Group H+, showing dashed lines denoting areas where the MO was Cut (left panel). SEM image of clot structure within the MO in Group H- showing that thrombus formed at the blood inlet surface, magnification x2,500 (right panel). See Beely et al.​

July/August 2016

• Table of Contents

Confluent Cell Coating on Sintered Ti. After ex vivo static culture (12 hr), rapid-seeded hCB-ECs formed a confluent cell monolayer on sintered Ti. (LEFT) Control sintered Ti surfaces without hCB-ECs (SEM); (CENTER) Rapid-seeded sintered Ti (SEM); (RIGHT) Rapid-seeded sintered Ti (Confocal Microscopy). (Rapid-seeding density: 0.9 x105 cells/cm2; blue, red and green color: nuclei, cytoplasm and cell junctions, respectively; scale bars: 100 μm.) See Noviani et al.

May/June 2016

• Table of Contents

Aortic arch geometry of five Norwood patients. Top row shows volumes from imaging data (with connecting tube extensions added), and bottom row shows the corresponding test phantoms. See Hang et al.

March/April 2016

• Table of Contents

Chest radiography showing left HVAD, occluded right HVAD, and second right HVAD connecting the right atrium to right main pulmonary artery. See Maltais et al.

January/February 2016

• Table of Contents

(Top) Geometry representation of the computational model of dialysis catheter in the superior vena cava (SVC). Red arrows indicate direction of flow. (Bottom) Close-up view of intravascular region of catheter demonstrating some of the computational mesh and zoomed-in views of specific regions of interest. See Richardson et al.

November/December 2015

• Table of Contents

Structure of 2-methacryloyloxyethyl phosphorylcholine surfaces. See Tchouta and Bonde.

September/October 2015

• Table of Contents

Three-dimensional computed tomography image. Fracture sites and regions of sternal nonunion are indicated by arrows preoperatively (left panel), and healed fractures are indicated by arrows at 3 months (middle panel) and 6 months postoperatively (right panel). See Khalpey et al.

July/August 2015

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ECG QRS complex patterns on day 2. Left: on LV anterior wall surfaces of recellularized hearts (QS or Rs); Right: on LV anterior wall surfaces of normal hearts (all are qR). See Tao et al

May/June 2015

• Table of Contents

Surgical implantation of pressure and flow sensors. The implant and battery are secured with sutures for short-term stability and wrapped in medical mesh that provides long term positional stability. See Fujii et al.

 

March/April 2015

• Table of Contents

CT Scan showing the location of the cannula tips (left panel) and early thrombosis of RVAD cannulas remnants (right panel).

January/February 2015

• Table of Contents

Representative tri-stained native and acellular ventricle tissues to define collagen type I (yellow), α-actinin sarcomeres (green)and nuclei (blue) components at 40x objective.

November/December 2014

• Table of Contents

Ascending aorta (left panel) and aortic valve (right panel) with C-Pulse explanted during heart transplantation.


September/October 2014

• Table of Contents

Map of the Reynolds’ shear stress downstream of a transcatheter aortic valve placed at different positions below the aortic annulus in a heart flow simulator. Magnitude of the shear stress is indicated in a color scale with blue being low values, green, yellow, orange and red indicating increasing values, respectively.

 

July/August 2014

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Diagram of the pediatric superior vena cava, right atrium, and central venous catheter in the 3D model volume.

May/June 2014

• Table of Contents

Axial CT view of the focal kink in the LVAD efferent cannula, proximal to the anastomosis into the ascending aorta, which causing 50% diameter stenosis. The anastomosis itself with the ascending aorta is patent measuring 12.2 mm in diameter (left), and reconstruction image, kink is marked with the large arrow (right).

March/April 2014

• Table of Contents

Optical image of the cross section of the sintered scaffold (left), and the external and internal structure of the optimized hydroxyapatite scaffold after the polymer binder and graphite were removed (right).
From DW Jang et al, Fabrication of Porous Hydroxyapatite Scaffolds as Artificial Bone Preform and its Bio-compatibility Evaluation
 

 

January/February 2014

• Table of Contents

Thrombus formation on the impeller part of the HeartMate II device identified postmortem from a patient with severe hemolysis.

From Hasin et al, The Role of Medical Management for Acute Intravascular Hemolysis in Patients Supported on Axial Flow LVAD.