Randomized controlled trials can provide optimal clinical evidence to assess the benefits of new devices, and it is these data that often shape device usage in real-world practice. However, individual clinical trial results sometimes appear discordant for the same device, and alternative devices are sometimes not employed in similar patient populations. To make sound evidence-based decisions, clinicians routinely rely on cross-trial comparisons from different trials of similar but not identical patient populations to assess competing technology when head-to-head randomized comparisons are unavailable.
From the *University of Washington, Seattle, Washington
†Northwestern Medical Center, Chicago, Illinois
‡Florida Hospital, Orlando, Florida
§Henry Ford Hospital, Detroit, Michigan
¶Tufts Medical Center, Boston, Massachusetts
‖Massachusetts General Hospital, Boston, Massachusetts
#Washington University School of Medicine, St. Louis, Missouri
**University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
††Medtronic (formerly HeartWare, Inc.), Framingham, Massachusetts
‡‡Stanford University Medical Center, Stanford, California.
Submitted for consideration October 2018; accepted for publication in revised form November 2018.
Disclosure: CM: Consultant / Investigator: Abbott, Abiomed, Medtronic. DTP: Consultant / Investigator Abbott, Medtronic. NAM: Consultant / Investigator: Abbott, Medtronic, Syncardia. SCS: Consultant / Investigator: Abbott, Medtronic. JC: Consultant / Investigator: Abbott. MSK: Consultant / Investigator: Medtronic. DAD: None. EEC: None. MFM: Consultant / Investigator: Medtronic. RLK: Consultant / Investigator: Abbott, Medtronic. MVJ: Employee: Medtronic. JJT: Consultant / Investigator: Abbott, Medtronic.
Correspondence: Claudius Mahr, University of Washington Medical Center 1959 NE Pacific St, AA121 Seattle, WA 98195. Email: firstname.lastname@example.org.
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