Secondary Logo

Journal Logo

Abstracts: ASAIO Bioengineering/tissue Engineering Abstracts

SINGLE POINT ATTACHED COMMISSURES” (SPAC) PERICARDIAL VALVE PROSTHESIS — EVALUATION IN A SHEEP MODEL

Goetz, Wolfgang A1; Tan, Teing Ee2; Lim, Khee Hiang1; Tan, Ru San3; Lim, Hou Sen4; Yeo, Joon Hock3

Author Information
  • Free

Purpose of study Recently new pericardial valve prosthesis made of pericardium has been developed (3F Therapeutics, Temporarily Stented Autologous Pericardial Valve Prosthesis). The base is sutured to the aortic annulus and the commissures are connected to the aortic wall at only three single points (SPAC). Our major concern was the reliability of the SPAC which made us evaluate this valve concept in an animal study. Methods Autologous pericardial valve prosthesis was constructed intraoperatively using a 3D-mold and was implanted in pulmonary position in six sheep undergoing cardiopulmonary bypass. The base of the valve prosthesis was sutured to the pulmonary valve annulus with 4–0 prolene interrupted sutures. Each commissure was sutured to the pulmonary trunk with one 4–0 prolene U-stitch. Echocardiography was performed intraoperatively and after 6 months before sacrifice. Transvalvular gradients were evaluated using Millar catheter. Specimens were taken for histological examination of commissural area. Results Echocardiography after implantation of SPAC valve prosthesis and before sacrifice, showed a competent valve with good and symmetrical valve mobility. The transvalvular gradient after implantation was 3.6+/−1.1 mmHg and at time of sacrifice 4.5+/−1.9 mmHg. After 6 month the commissures appeared intact with no tears and histology examination revealed that all commissures were securely anchored in the pulmonic wall.

Copyright © 2005 by the American Society for Artificial Internal Organs