Secondary Logo

Journal Logo

Abstracts: ASAIO Cardiac Abstracts

“INITIAL, CONTINUOUS AND INYETMITTENT BOLUS” ADMINISTRATION OF MINIMALLY-DILUTED BLOOD CARDIOPLEGIA SUPPLEMENTED WITH POTASSIUM AND MAGNESIUM FOR HYPERTROPHIED HEARTS

Hayashi, Yoshitaka1; Ohtani, Masakatsu1; Hiraishi, Taizo1; Kobayashi, Yasuhiko1; Nakamura, Takayuki1

Author Information
  • Free

Hypertrophied hearts are subject to the deleterious effects of ischemia-reperfusion. This study was designed to elucidate an efficacy of “initial, continuous and intermittent bolus” administration of minimally-diluted blood cardioplegia (mini-BCP) in patients with hypertrophied hearts. Thirty patients (M:F=17:13, 69.2±7.8 years) with left ventricular mass index greater than 120g/m2 undergoing aortic valve replacement between 1996–2002 were enrolled. Group C (n=15) received standard 4:1-diluted BCP, and Group M (n=15) were given mini-BCP supplemented with potassium (initial/others: 15.4/9.8 mEq/L) and magnesium (6.5/4.0 mEq/L). Initial and intermittent (every 20 min) BCP was infused for 2 min at the rate of 200 mL/min. Continuous BCP flow rate was set around 60–100mL/min. Stable cardiac arrest was maintained during aortic clamping in all study patients, and total crystalloid amount as cardioplegia was greater in Group M (M vs C; 79±28 vs 937±372mL, p<0.01). Group M showed higher incidence of spontaneous heart beat recovery (13 vs 6, p<0.05). Postoperatively, maximum dopamine dose (3.4±2.3 vs 5.5±2.3 ug/kg/min, p<0.05) and peak plasma CK-MB (21.7±7.2 vs 28.8±8.4 IU/L, p<0.05) were lower in Group M. “Initial, continuous and intermittent bolus” administration of mini-BCP, supplemented with potassium and magnesium, is a novel modification in terms of simplifying the maintenance of hyperpolarized arrest with beneficial myocardial protective effects for hypertrophied hearts.

Copyright © 2005 by the American Society for Artificial Internal Organs