Abstracts: ASAIO Cardiac Abstracts
TOTAL ARTIFICIAL HEART UTILIZING DUAL INTRACORPOREAL CONTINUOUS FLOW PUMPS IN A CHRONIC BOVINE MODEL
Total artificial hearts (TAH) may be anatomically unsuitable for implantation in 60% of the population (small adults, children). Continuous flow pumps are smaller, more power-efficient, and conducive to biventricular replacement. We used dual Jarvik 2000 Flowmakers as a TAH in a juvenile bovine model.
Ventricles were transected below the atrial junction. A pericardial patch was sewn to each ventricular remnant to support the pump sewing ring. Aorta (Ao) and pulmonary artery (PA) were transected above the valves for end-to-end anastomosis of outflow grafts. Pump speed was constant (14 Krpm) on the left and varied (8–12 Krpm) on the right. Vascular resistances were managed pharmacologically.
Pump flows (L/min) averaged 7.6±1.1 on the left and 7.2±1.1 on the right. Pressures (mmHg) were 98±17 (Ao), 19±6 (PA), 12±7 (LA), and 17±6 (RA). End-organ function and blood ANF, TNF, ACE and catecholamine levels remained normal. The animal died on day 20 when right pump controller accidentally separated from its power supply.
We showed feasibility of an implantable, constant-flow TAH. Preload sensitivity of rotary pumps allowed adequate compensation of left-sided flow imbalance without an ASD or internal balancing mechanism.Copyright © 2005 by the American Society for Artificial Internal Organs