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Abstracts: ASAIO Bioengineering/tissue Engineering Abstracts

STABLE BUBBLE RELEASE FROM MECHANICAL HEART VALVES IN A MOCK CIRCULATORY FLOW LOOP

Bieniek, Jared1; Manning, Keefe B1; Fontaine, Arnold A1; Tarbell, John M2; Deutsch, Steven1

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There is some evidence that dissolved carbon dioxide (as compared to other atmospheric gases) in blood may promote stable bubble formation in mechanical heart valve (MHV) cavitation. A physiological flow-through loop is used to study the effect of varying levels of carbon dioxide on the occurrence of stable bubbles during MHV cavitation. The flow loop is driven by a piston pump that provides a pulsatile flow. Three CO2 levels (0, 40, and 100 mmHg) are added to degassed water with digital cameras used to capture the cavitation and stable bubbles. Images of mitral valve cavitation (Bjork-Shiley Monostrut mechanical heart valve) show no significant changes in vortex or bubble cavitation between trial runs at constant dissolved carbon dioxide levels. While performing digital video acquisition of stable bubbles distal to the MHV, we observe an increased presence of stable bubbles in the flow with increasing dP/dt (while at constant carbon dioxide concentrations). Also, the number of stable bubbles increases with increasing carbon dioxide concentration (3 trials with no loaded gases and 3 trials at 100mmHg CO2). The data suggests that dissolved CO2 provides a mechanism for the formation of stable bubbles and may play a role in mechanical heart valve implanted related strokes and neurologic deficits.

Copyright © 2005 by the American Society for Artificial Internal Organs