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Abstracts: ASAIO Bioengineering/tissue Engineering Abstracts


Ash, Stephen R1,2; Sullivan, Thomas A1; Carr, David J1

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The selective chemical binding of sorbents is well suited to treatment of hepatic failure and drug overdose. The Sorbent Suspension Reactor (SSR) is a dialysate regenerating device in which a suspension of powdered activated carbon is enclosed by a cylindrical sheet membrane. A rotating paddle and shunts create a high shear rate at the membrane surface on the reactor wall without excessive particle density polarization. A standard hemodialysis machine operates the extracorporeal blood circuit, including a hollow fiber dialyzer; the SSR system replaces the single-pass dialysate system with a dialysate-regenerating reactor. At dialysate flow rate = 450 mL/min, SSR should remove most toxins, resulting in water-soluble toxin clearance by SSR/hemodialysis system equal to the BioLogic-DT™. The DT was FDA-approved and clinically used to treat hepatic encephalopathy and drug overdose. A prototype SSR has chemical performance similar to the DT. Creatinine binding of activated carbon in the SSR generally exceeds theoretical equilibrium binding of a well-mixed suspension. A full-scale reactor has been constructed and has demonstrated capability to regenerate dialysate at flow = 450 mL/min. Tests are now beginning to confirm clearance rates for various small molecular weight toxins. Tests have also shown that SSR can also treat dialysate containing 5% albumin at flow rates in excess of 100 mL/min. When further developed, SSR will allow extracorporeal detoxification by powdered sorbents with the same efficacy as the DT but with greater simplicity, biocompatibility, and flexibility.

Copyright © 2005 by the American Society for Artificial Internal Organs