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Abstracts: ASAIO Bioengineering/tissue Engineering Abstracts

POLY(D,L-LACTIC ACID) NANOSPHERES CONTAINING DAUNORUBICIN INTENDED FOR TACE TREATMENT

Zhang, S M1,3; Cao, R R2; Liu, J1; Zhou, W1; Wang, D F4; Cheng, L1; Luo, Q M3

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Hepatocellular carcinoma (HCC) is one of the commonest malignant tumors in the world, especially popular in Asian. For most unresectable HCC patients, transcatheter arterial chemoembolization (TACE) is a preferred choice. The TACE method involves the selective arterial embolization of a tumor together with the simultaneous or subsequent local delivery of chemotherapeutic agents. The efficiency of TACE will be further improved by using biodegradable polymeric nano-device for controlled release. This paper proposes to fabricate a poly (d, l-lactic acid) (PDLLA) nanospheres used in the chemotherapy process of TACE. Daunorubicin (DNR) is chose as model drug. The PDLLA nanospheres containing DNR are prepared using a simultaneous double-emulsion (water-in-oil-in-water) solvent evaporation/extraction process. The morphology of the nanospheres is characterized by FE-SEM and TEM, their size and distribution are tested by laser light scattering method. Drug contents in the nanospheres are calculated through UV spectrophotometer method. As a result, regular spherical PDLLA nano-devices containing DNR are obtained. Size of the nanospheres obeys normal distribution centered in 300 nm. The diameters of most single nanoparticles are below 100 nm with a slight aggregation of particles in the external water phase. Finally, the drug release experiments are also investigated. Current work provides a new possible application for PDLLA nano-drug delivery system in TACE treatment.

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