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Abstracts: ASAIO Bioengineering/tissue Engineering Abstracts


Kreider, James W1; Manning, Keefe B1; Oley, Leslie A1; McSweeney, Thea M1; Fontaine, Arnold A1; Deutsch, Steven1

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We investigate the flow field associated with mitral valve orientation in the Penn State 50 cc assist device. The Penn State 70 cc assist device does not suffer thrombus formation, however, clots have been discovered in animal implantations of the newer scaled down 50 cc device. There is some evidence that flow stasis near the walls of the assist device contributes to clot formation. The controlling factor of the flow characteristics in the device is the inflow through the mitral valve. Therefore, the orientation of this valve is important. Using particle image velocimetry (PIV), we rotated the Bjork-Shiley Monostrut mitral valve from 0° to 90°, in 15° increments, in a prototype of the 50 cc Penn State assist device, and have investigated the flow fields associated with each orientation. For each orientation, we measured whole planar flow fields in three planes (3, 5, and 7 mm) from the front of the device. Since PIV techniques can be used to relatively quickly measure the planar flow characteristics, it is an excellent tool to use in comparing resultant flow fields at the different valve orientations. We then used these comparisons to find the best orientation for the mitral valve to minimize flow stasis and risk for clot formation along the walls of the device.

Copyright © 2005 by the American Society for Artificial Internal Organs