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Abstracts: ASAIO Bioengineering/tissue Engineering Abstracts

FAST WET SYNTHESIS OF NANO-FLUORIDE-SUBSTITUTED HYDROXYAPATITE

Zhou, W1,2; Zhang, S M1,2; Zhou, S L2; Liu, J1,2; Wang, D F3; Luo, Q M2

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Fluoride-substituted hydroxyapatite (F-HAP) has been the important bioceramics for its similarity to the real human hard tissues in component. However, its artificial synthesis requires a lot of time (12–48 hours). The current paper reports a fast synthesis of F-HAP and the resulting F-HAP is nano-size. The nano-F-HAP is synthesized by a precipitation method, involving adding 80ml of 60 mmol/l NH4H2PO4 solution containing 0.0296 g NH4F to 80 ml of 100 mmol/l Ca(CH3COO)2H2O solution, followed by introducing supersonic for 30 min. Then 160 ml of 1.3mol/l NH4(CH3COO) solution is added to the former solution under supersonic environment and stirred for 3 h. All reactions are conducted at 80°, and the pH is maintained at 7.4. Finally, slurries are centrifugalized, washed with distilled water and dried at 80°. The nano-F-HAP crystals are characterized by XRD, SEM, HR-TEM and FT-IR. XRD diffraction patterns of the nano-crystals correspond to the standard data. IR spectra indicate absence of peaks, 633cm-1 and 3570cm-1, of OH-groups in hydroxyapatite, suggesting the substitution of F for OH. TEM pictures show that most crystals are in the shape of short rods and some are needle-like. Short rods may be caused by the use of supersonic during the synthesis process. Size of all the crystals is below 100 nm. This work shows that it is possible to synthesis nano-F-HAP in a short time (less than 3 hours), which further supports the following application of fluoride isotope labeled HAP in the positron emission tomography (PET) molecular imaging.

Copyright © 2005 by the American Society for Artificial Internal Organs