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Abstracts: ASAIO Bioengineering/tissue Engineering Abstracts


Lee, Hwansung1; Tsukiya, Tomonori1; Homma, Akihiko1; Kamimura, Tadayuki1; Tatsumi, Eisuke1; Takano, Hisateru1; Taenaka, Yoshiyuki1; Kitamura, Soichiro1

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The purpose of this study was to establish an estimation method for mechanical in vitro heart valve cavitation with an electro-hydraulic total artificial heart (EHTAH). To estimate the MHV cavitation, we used the left driving pressure (LDP) slope as the cavitation intensity. The LDP slope was controlled by changing the stroke volume of the EHTAH. The stroke volume was changed from full-filling and full-eject (FFFE) to partial-filling and partial-eject (PFPE) conditions. A 25-mm Medtronic Hall valve with opening angles of 70°was installed in the mitral position of the EHTAH. As the working fluid, a 50% glycerin solution was used. Cavitation bubbles were recorded at 30,000 frames/sec with a high-speed camera. Cavitation bubbles were concentrated on the valve stop; the major cause of these cavitation bubbles was determined to be squeeze flow. The formation of cavitation bubbles depended on the valve stop and the valve stop geometry. The valve-closing velocity and the cavitation intensity and the event rate of the cavitation occurrence increased with increases in the LDP slope. The LDP slope of the EHTAH may play an important role in estimating the MHV cavitation intensity. From the perspective of MHV cavitation, the PFPE condition is safer with regard to preventing blood cell damage and valve surface erosion than the FFFE condition.

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