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Abstracts: ASAIO Bioengineering/tissue Engineering Abstracts

BLOOD-SOLUBLE DRAG-REDUCING POLYMERS AS A POTENTIAL TREATMENT OF HEMODYNAMIC IMPAIRMENT IN DIABETIC RATS

Marascalco, Philip J1,2; Marhefka, Joie N1,2; Shaulis, Stephanie T1; Johnson, Chenara A1; Kameneva, Marina V1,2

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BACKGROUND:

Diabetes is associated with generalized afflictions of the cardiovascular system. Current therapies can at best delay the onset of these complications. Intravenous injections of blood-soluble drag reducing polymers (DRPs) were shown to increase blood flow and tissue perfusion and reduce vascular resistance without affecting the vessel wall. We hypothesized that DRPs might enhance the microcirculation which is thought to be reduced in diabetes.

METHODS:

Diabetes was induced in 7 rats after a single dose of streptozotocin (vehicle in controls, n = 8) and characterized by blood glucose levels of 300–400 vs. 80–90 mg/dl in controls. Insulin (0.5–3 U) was administered to maintain blood glucose levels below 450 mg/dl. After 15 weeks of hyperglycemia, DRPs were injected IV at a final concentration of 1 ppm following recording of base hemodynamic parameters in acute experiments. Blood samples were collected before and after DRP infusion.

RESULTS:

Body weight, tissue perfusion (TP), MAP and heart rate were significantly lower and vascular resistance and hematocrit were both significantly higher in diabetic animals. An injection of DRPs increased TP by ∼40% in both control and diabetic rats with no significant change in MAP.

CONCLUSIONS:

This study demonstrated that DRPs were able to improve impaired TP in diabetic animals and may represent a new rheological method for the treatment of impaired microcirculation in diabetes.

Copyright © 2005 by the American Society for Artificial Internal Organs