Abstracts: ASAIO Bioengineering/tissue Engineering Abstracts
A NOVEL DEVICE TO RETROPERFUSE THE CORONARY BED
The purpose of this project is to design, fabricate, and test the AutoRetroPerfusion Cannula (ARC) to treat inoperable coronary disease patients. ARC retroperfuses the coronary bed through the coronary sinus (CS) with arterial blood diverted from an artery without a pump.This device was tested in an in vitro mock loop simulating in vivo use.
The distal end when secured in the CS deploys an umbrella-like membrane to partially occlude and create pressure in the CS.Small channels directed backwards to the right atrium provide CS pressure and flow relief.The ARC is introduced from the axillary vein under local anesthesia and a graft at the proximal end is anastomosed to the axillary artery to begin auto-retroperfusion when the distal end is secured in the CS and the occluding membrane is open.
Tested in an in vitro mock loop under 50–120mmHg of proximal pressure and 50,100 and 150ml/min of total flow in the cannula, the nominal design point of 40–80mmHg of distal pressure and 50–150ml/min of distal flow was achieved by adjusting the number,diameter and length of the backwards channels.
in vitro testing met the design criteria of a new, implantable AutoRetroPerfusion Cannula.Copyright © 2005 by the American Society for Artificial Internal Organs