Abstracts: ASAIO Pulmonary Abstracts
A NEWLY DEVELOPED VENTILATOR PROTOTYPE FOR NEONATAL TOTAL LIQUID VENTILATION
Total liquid ventilation (TLV) seems to give significant advantages when preterm infants are concerned, but requires a dedicated ventilator to process the liquid perfluorocarbons (PFC). A new prototype volume-controlled, pressure-limited ventilator was developed and used for preliminary in vivo animal tests.
The ventilator comprises a stepper-motor actuated double-piston system performing respiratory cycles and an uncoupled refresh circuit to achieve PFC filtration, thermostatting, oxygenation, and CO2 scavenging. A personal computer-based control system manages the two sub-circuits. The apparatus was tested using FC-77 in preliminary animal experiments on 4 New Zealand Rabbits (test lasting 4 hours) and 4 preterm lambs (gestational age 110±5 days; test lasting 6 hours). Control animals (n=2) were gas ventilated. At the end of each experiment, lungs were excised and processed for light microscopy in order to verify airway and lung parenchyma condition.
During TLV, adequate gas exchanges (arterial pO2=176 mmHg, pCO2= 45 mmHg) and blood pressure were maintained in the rabbits, while good oxygenation (pO2=94 mmHg) and moderate hypercapnia (pCO2=65 mmHg) were recorded during lamb experiments. Histological analysis showed neither atelectasis nor signs of inflammation in the TLV-ventilated animals.Copyright © 2005 by the American Society for Artificial Internal Organs