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Yambe, T1; Abe, Y2; Tabayashi, K3; Nitta, S1; Imachi, K2; Shiraishi, Y1; Yoshizawa, M4

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The development of an implantable type Uudulation Pump ventricular assist device (UPVAD) has recently progressed in Japan. Six universities and several companies have collaborated for the purpose of this development project for a period ranging from 2002 to 2007. In this study, we investigated the influence of the currently developing UPVAD on internal-organs circulation. Coats, with weights equal to those of an average Japanese individual were used in the experiment. The left chest cavity was opened after the fourth rib resection and the heart was approached. A cannula was inserted into the ventricle from the apex. An out flow cannula was inserted into the descending aorta. The heart muscle was excised using the newly developed puncher. The UPVAD was implanted through the left heart bypass system. The myocardial blood flow, carotid arterial blood flow, and the kidney blood flow were. As a result of the animal experiments, the hemodynamic parameters were stabilized and sufficient left-heart supporting effect was observed. Myocardial blood flow, carotid arterial flow, and kidney blood flow showed a tendency to increase on account of the UPVAD support. The problem of multiple organ failure is critical during the clinical application of a ventricular assist device. Assistance of internal-organs circulation plays an important role in the prevention of multiple organ failure. Thus, it was concluded that UPVAD might be useful in the prevention of multiple organ

Copyright © 2004 by the American Society for Artificial Internal Organs