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ASAIO CARDIAC ABSTRACT

STATIC CARDIOMYOPLASTY WITH SYNTHETIC ELASTIC NET SUPPRESSES VENTRICULAR DILATATION AND HEART FAILURE AFTER MYOCARDIAL INFARCTION IN THE RAT

Kawaguchi, A T1; Yamaoka, T2; Kishida, A3

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Background. Dynamic cardiomyoplasty with own skeletal muscle was reported to reduce ventricular dilatation and improve function. We tested chronic effect of synthetic net after myocardial infarction (MI) in therat. Methods. Pressure-volume (PV) relationships were analyzed before, after volume load (saline 1% of body weight), and 10 minutes after occlusion of the left anterior descending artery. Rats were randomized into groups receiving synthetic net around the heart (NET+, n = 5) and nothing (NET-, n=5), and underwent the same PV studies 6 weeks later. End-diastolic and end-systolic PV relationships were defined and left ventricular size and function compared under standardized loading conditions. Results. Increase in left ventricular end-diastolic (EDV) and end-systolic volumes (ESV) were significantly suppressed in NET+ rats, resulting in preserved stroke volume (SV) and significantly improved ejection fraction (EF) 6 weeks after MI (Table). Presence or absence of net did not yield significant difference under acute volume load. Conclusion. Static rardiomyoplasty using synthetic elastic net significantly suppress ventricular dilatation and functional deterioration without restriction long-term after MI in the rat. Net material and elasticity need to he adjusted for optimal girdling effect.

Table 6
Table 6:
weeks after MI
Copyright © 2004 by the American Society for Artificial Internal Organs