Secondary Logo

COMPARATIVE STUDY OF THE EFFECTS OF PULSATILE AND NONPULSATILE FLOW ON THE HEMODIALYSIS EFFICIENCY; PRELIMINARY STUDY

Lee, J C1; Kim, J C1; Park, J Y1; Park, C Y1; Min, B G2,3

ASAIO RENAL ABSTRACTS
Free

1Interdisciplinary Program in Medical and Biological Engineering Major, Graduate School-,Seoul National University, Seoul, Korea

2Department of Biomedical Engineering, College of Medicine, Seoul National University; Seoul, Korea

3Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul, Korea

Since hemodialysis system has been developed, nonpulsatile roller pump has been the “gold standard” for blood circulatory pump for a long time. Recent studies showed that the pulsatile blood perfusion through the kidney provides more urine output and better preservation of kidney for organ transplantation. To study the effect of pulsatile flow on the efficiency of hemodialysis, a roller pump was substituted with a newly developed pulsatile blood pump. The solution of blood substitute was prepared as 0.9% saline solution containing urea, creatinine and vitamin B12. The 0.9% saline solution was used as the dialysate. Two types of the hollow fiber dialyser, the normal flux dialyser and the high flux dialyser, were employed to consider the pore size of dialyser. Mock circulation tests of in-vitro dialysis circuits were performed 10 times in each condition. The clearance of each solute was calculated by the change of the concentration after test. The ultrafitration rate was calculated with the pressure difference of blood and dialysate through the hollow fiber dialyser. The results showed that both the clearance and the ultrafitration rate of each solute in pulsatile flow group were wholly higher than those in nonpulsatile group. We concluded that pulsatile flow was more efficient in hemodialysis than nonpulsatile flow, and that the newly developed pulsatile pump was able to be substituted for conventional roller pump in hemodialysis system.

Copyright © 2003 by the American Society for Artificial Internal Organs