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INFLUENCE OF THE FLOW PATTERNS ON THE MICROCIRCULATION OF THE BULBAR CONJUNCTIVA IN THE GOAT IMPLANTED A TOTAL ARTIFICIAL HEART

Baba, A.; Dobsak, P.*; Saito, I.; Ishimaru, M.; Isoyama, T.; Takiura, K.; Shihata, M.; Abe, Y.; Chinzei, T.; Vasku, J.*; Imachi, K.

ASAIO CARDIOPULMONARY ABSTRACTS
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1Univ. of Tokyo, Tokyo, Japan

2Masaryk Univ., Brno, Czech Republic.

To investigate the influence of flow patterns on the microcirculations (MC) in the goat implanted a total artificial heart (TAH), a new system to observe the MC of the bulbar conjunctiva at the wake condition was developed. The digital high definition microscope that equipped on the 3-D stage fixed to a headgear of the goat was used to observe the MC.

We implanted the undulation pump total artificial heart (UPTAH) to the goat, which can produce arbitrary flow patterns by computer control. When the whole body condition of TAH goat became stable after the surgery, we changed the flow pattern from pulsatile to non-pulsatile and observe the change in the MC.

At first, we could observe that the arterioles were constricted, and the velocity of erythrocytes in the capillaries dropped remarkably. About 10 minutes later, the arterioles were dilated and the velocity of erythrocytes in the capillaries recovered to the initial level.

These results indicate that at the acute phase of the flow pattern change from pulsatile to non-pulsatile, the baroceptor sensed the arterial pressure decrease and the sympathetic nerve activity increased, and the arterioles were constricted. After that the accumulation of products due to metabolism of the tissue led to the dilation of the arterioles.

Copyright © 2002 by the American Society for Artificial Internal Organs