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ASAIO CARDIOPULMONARY ABSTRACTS

HEMOLYSIS CHARACTERISTICS OF A NEW TYPE-INTRAVENOUS LUNG ASSIST DEVICE

Lee, S. C.1; Kim, K. B.2; Hong, S. T.2; Kim, M. H.2; Kwon, D. K2; Jheong, G. R.2

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The purpose of this study was to investigate the effect of multiple mechanical forces in hemolysis. Specific attention was focused on the effect of membrane vibration. This study was design to identify membrane vibration dependence on hemolysis, and provide verification data for a developing a device.

For the hemolysis test, the plasma free hemoglobin concentration was measured spectrophotometrically with a Shimadzu assay kit. The normalized index of hemolysis(NIH) was calculated according to a linear regression analysis method. The normalized index of hemolysis for the oxygenator(NIHO) has been modified according to the ASTM standards. The NIH value, which was obtained from the circuit without an oxygenator, was subtracted from the circuit with an oxygenator to eliminate the effects of the roller pump or other artifacts. This value was defined as the value of NIHO. The blood flow was fixed at 1 L/min as in an ECMO condition and 5 L/min as a cardiopulmonary bypass condition (V/Q ratio = 1).

The NIH values of the circuit, including the intravenous lung assist device, were 0.0014(g/100L) by exciting a piezo-vibrator with the sine wave magnitude of DC 10V and 0.0018(g/100L) at 50 V. The NIH values of the circuit without the oxygenator were 0.00043 (g/100L) by exciting a piezo-vibrator with the sine wave magnitude of DC 10V and 0.00072 (g/100L) at 50 V. By subtracting these numbers, The NIHO value could he determined as 0.00097(g/l00L) and 0.00108(g/100L) by exciting a piezo-vibrator with the sine wave magnitude of DC 10V and 50 V, respectively

Copyright © 2002 by the American Society for Artificial Internal Organs