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Comparative Bone Regeneration Potential Studies of Collagen, Heparin, and Polydopamine-Coated Multichannelled BCP Granules

Lee, Gun Hee*; Makkar, Preeti; Paul, Kallyanshis; Lee, Byong Taek*†

doi: 10.1097/MAT.0000000000000582
Tissue Engineering/Biomaterials

The current study is a comparative assessment of the bone regeneration potentiality of bone substitutes composed of bioactive polymer–coated biphasic calcium phosphate (BCP) granules. The bone substitutes were primarily composed of multichanneled BCP granules, which were coated separately with biochemical polymer coatings, namely collagen, heparin, or polydopamine (PD), using chemical methods. The morphologic features and chemical structure of the granules and surface coatings were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy, respectively. The biological characterizations in terms of cellular interaction with the bone substitutes in vitro (MTT assay and proliferation) and in vivo (bone regeneration efficacy) were performed and compared with uncoated BCP granules. It was found that PD-coated BCP granules were superior to the others with respect to promoting more rapid healing. Therefore, PD multichannel BCP granule system can be used as a promising injectable bone substitute for clinical applications.

From the *Department of Regenerative Medicine, College of Medicine and Institute of Tissue Regeneration, Soonchunhyang University, Cheonan, South Korea.

Submitted for consideration January 2017; accepted for publication in revised form March 2017.

Disclosure: The research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (No. 2015R1A2A1A10053272) and partially supported by SoonChunHyang University, S Korea. The authors have no conflicts of interest to report.

Correspondence: Byong Taek Lee, Department of Regenerative Medicine and Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, 366-1 Ssangyong dong, Cheonan, 330-090, South Korea. Email:

Copyright © 2018 by the American Society for Artificial Internal Organs