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Design and Development of a Miniaturized Percutaneously Deployable Wireless Left Ventricular Assist Device: Early Prototypes and Feasibility Testing

Letzen, Brian*; Park, Jiheum*; Tuzun, Zeynep*; Bonde, Pramod

doi: 10.1097/MAT.0000000000000669
Original Article: PDF Only

The current left ventricular assist devices (LVADs) are limited by a highly invasive implantation procedure in a severely unstable group of advanced heart failure patients. Additionally, the current transcutaneous power drive line acts as a nidus for infection resulting in significant morbidity and mortality. In an effort to decrease this invasiveness and eliminate drive line complications, we have conceived a wireless miniaturized percutaneous LVAD, capable of being delivered endovascularly with a tether-free operation. The system obviates the need for a transcutaneous fluid purge line required in existing temporary devices by utilizing an incorporated magnetically coupled impeller for a complete seal. The objective of this article was to demonstrate early development and proof-of-concept feasibility testing to serve as the groundwork for future formalized device development. Five early prototypes were designed and constructed to iteratively minimize the pump size and improve fluid dynamic performance. Various magnetic coupling configurations were tested. Using SolidWorks and ANSYS software for modeling and simulation, several geometric parameters were varied. HQ curves were constructed from preliminary in vitro testing to characterize the pump performance. Bench top tests showed no-slip magnetic coupling of the impeller to the driveshaft up to the current limit of the motor. The pump power requirements were tested in vitro and were within the appropriate range for powering via a wireless energy transfer system. Our results demonstrate the proof-of-concept feasibility of a novel endovascular cardiac assist device with the potential to eventually offer patients an untethered, minimally invasive support.

From the *Bonde Artificial Heart Lab, Yale School of Medicine, New Haven, CT; and Yale School of Medicine, New Haven, CT.

Submitted for consideration October 2015 ; accepted for publication in revised form August 2017.

Supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Number T3511L007649 and by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number TL1TR000141. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Disclosure: The authors have no conflicts of interest to report.

Correspondence: Pramod Bonde, Center for Advanced Heart Failure and Transplantation, Yale School of Medicine, Yale New Haven Hospital, 330 Cedar Street, 204 Boardman, PO Box: 208039, New Haven, CT. E-mail:

Copyright © 2018 by the American Society for Artificial Internal Organs