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Low-Resistance, Concentric-Gated Pediatric Artificial Lung for End-Stage Lung Failure

Thompson, Alex J.*; Buchan, Skylar*; Carr, Benjamin*; Poling, Clinton*; Hayes, McKenzie*; Fernando, U. Piyumindri*; Kaesler, Andreas; Schlanstein, Peter; Hesselmann, Felix; Arens, Jutta; Potkay, Joseph A.*; Rojas-Pena, Alvaro*; Bartlett, Robert H.*; Hirschl, Ronald B.*

doi: 10.1097/MAT.0000000000001018
Original Article: PDF Only

Children with end-stage lung failure awaiting lung transplant would benefit from improvements in artificial lung technology allowing for wearable pulmonary support as a bridge-to-transplant therapy. In this work, we designed, fabricated, and tested the Pediatric MLung—a dual-inlet hollow fiber artificial lung based on concentric gating, which has a rated flow of 1 L/min, and a pressure drop of 25 mm Hg at rated flow. This device and future iterations of the current design are designed to relieve pulmonary arterial hypertension, provide pulmonary support, reduce ventilator-associated injury, and allow for more effective therapy of patients with end-stage lung disease, including bridge-to-transplant treatment.

From the *Extracorporeal Life Support Laboratory, Department of Surgery, University of Michigan, Ann Arbor, Michigan

Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, Germany.

Submitted for consideration October 2018; accepted for publication in revised form March 2019.

Disclosure: The authors have no conflicts of interest to report.

This work was supported by the National Institutes of Health grant 2R01 HD015434-34.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML and PDF versions of this article on the journal’s Web site (

Correspondence: Alex J. Thompson, VA Ann Arbor Healthcare System, Ann Arbor, MI. Email:

Copyright © 2019 by the American Society for Artificial Internal Organs