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Calcium Priming of the Central Venous Catheter Prevents a Drop in Ionized Calcium Concentration During Regional Citrate Anticoagulation

Roveri, Giulia*; Busana, Mattia*; Lusardi, Andrea Clarissa*; Ferrari, Federica*; Trevisan, Giacomo*; Di Girolamo, Luca*; Dei Poli, Marco; Resta, Marco Vittorio

doi: 10.1097/MAT.0000000000000911
Original Article: PDF Only

During citrate-based Continuous Renal Replacement Therapy (CRRT), an infusion of calcium is necessary to replace the calcium lost in the effluent. The replacement takes place through a central venous catheter (CVC) that is primed with saline solution. Thus, we hypothesized a potential systemic anticoagulation because of unchelated citrate reaching the patient at the start of CRRT because of 0.42 ml of line dead space. In this pilot study, two subpopulations of 7 patients who underwent Continuous Veno-Venous Hemodiafiltration (150 ml/min of blood flow, 1500 ml/h dialysate, 1500 ml/h of citrate predilution) were studied. One had the CVC primed with saline, the second with calcium chloride. Calcium replacement rate was 6.3 ± 0.2 ml/h. Ionized calcium concentration was studied over time in the two groups, in the group with saline priming we detected a transient period of hypocalcemia (ionized calcium concentration [iCa] < 1.00 mmol/L for the first 2 hours). In the subpopulation with the calcium priming, this was not present. No significant effect on filter life emerged. Priming of the catheter with calcium seems effective in avoiding a potential issue regarding citrate accumulation at the start of CRRT. More studies are needed to assess the clinical significance of this finding.

From the *Department of Medical-Surgical Physiopathology and Transplants, University of Milan, Milan, Italy

Department of Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Italy.

Submitted for consideration May 2018; accepted for publication in revised form September 2018.

Disclosure: The authors have no conflicts of interest to report.

The study was funded by Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, San Donato Milanese (MI), Italy.

Correspondence: Mattia Busana, Università degli Studi di Milano. Email:

Copyright © 2019 by the American Society for Artificial Internal Organs