Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Hemoadsorption does not Have Influence on Hemolysis During Cardiopulmonary Bypass

Bernardi, Martin H.*; Rinoesl, Harald; Ristl, Robin; Weber, Ulrike*; Wiedemann, Dominik§; Hiesmayr, Michael J.*

doi: 10.1097/MAT.0000000000000897
Renal/Extracorporeal Blood Treatment

Cardiopulmonary bypass (CPB) induces hemolysis, which manifests as plasma free hemoglobin. We investigated in a post hoc analysis of a single-center, blinded, controlled study whether the use of a novel hemoadsorption device (CytoSorb, CytoSorbents Europe GmbH, Berlin, Germany) affects hemolysis during CPB. A total of 35 patients undergoing elective CPB surgery with an expected CPB duration of more than 120 min were included in the analysis. The hemoadsorption device was used in 17 patients (intervention group) and not used in 18 patients (control group). The primary outcome was differences of postoperative free hemoglobin and haptoglobin levels. As secondary outcomes, we investigated differences in postoperative lactate dehydrogenase and bilirubin levels. Postoperative free hemoglobin levels were not significantly different between the groups. However, there were statistically significant differences between the treatment and control groups in the median levels of haptoglobin (58.4 vs. 17.9 mg/dL, respectively; P < 0.01) and lactate dehydrogenase (353.0 vs. 432.0 U/L, respectively; P < 0.05) on postoperative day 1. Thus, in this study, we did not find an effect on hemolysis in patients treated with hemoadsorption, though lower haptoglobin level and higher secondary hemolysis markers on postoperative day 1 in patients not treated with the hemoadsorber may be an indication of some moderate effect of the device. Studies with larger samples are needed to clarify the significance of the small differences detected in this study.

From the *Division of Cardiac Thoracic Vascular Anesthesia and Intensive Care Medicine, Medical University of Vienna, Vienna, Austria

Department of Anesthesia and Intensive Care Medicine, Landeskrankenhaus Feldkirch, Feldkirch, Austria

Centre for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria

§Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.

Twitter: @Twitter

Submitted for consideration May 2018; accepted for publication in revised form September 2018.

Disclosure: M.H.B. and M.J.H. have received travel funding for a lecture from CytoSorbents Europe, GmbH. The other authors have no conflict of interest to declare.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML and PDF versions of this article on the journal’s Web site (

For this post hoc analysis, no funding was needed. The original study was partly financially supported by CytoSorbents Europe, GmbH. All other funding for laboratory measurements and human resources was departmental and institutional.

Correspondence: Martin H. Bernardi, Division of Cardiac Thoracic Vascular Anesthesia and Intensive Care Medicine, Medical University of Vienna, Waehringer Guertel 18–20, A-1090 Vienna, Austria. Email:

Copyright © 2019 by the American Society for Artificial Internal Organs