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Leaflet Kinematics of Mechanical and Bioprosthetic Aortic Valve Prostheses

Vennemann, Bernhard*,†; Rösgen, Thomas*; Heinisch, Paul Philipp; Obrist, Dominik

doi: 10.1097/MAT.0000000000000687
Biomedical Engineering

The hemodynamic performance of artificial aortic valves (AVs) and the probability for structural valve deterioration can be linked to the valve kinematics. Comparability among different studies is limited because of variations in the experimental setups and physiologic boundary conditions. This study presents results of kinematic measurements of bioprosthetic and mechanical AVs that were tested in an identical experimental setting such that they can be directly compared with each other. The kinematics of AVs is typically presented in the form of the geometric orifice area and its temporal evolution. These parameters cannot capture asynchronous leaflet motion and out-of-plane leaflet velocity. In this work, each leaflet was tracked individually for a more detailed understanding of the leaflet kinematics, asynchronous leaflet motion, and leaflet tip velocities. A bioprosthetic valve, Edwards INTUITY (EINT), and two mechanical valves, Medtronic ADVANTAGE (MADV) and a Lapeyre-Triflo FURTIVA (TFUR), were tested in a compliant model of the aortic root in a physiologic flow loop. TFUR and MADV opened alike with maximum leaflet tip velocities of 0.77 and 0.66 m/s, respectively. The opening of EINT showed significantly higher local in-plane leaflet velocities of more than 2 m/s. EINT and TFUR exhibited similar early and slow closure. MADV closed significantly later with increased velocity. TFUR had a median maximum leaflet tip velocity of 0.39 m/s during valve closure and that of MADV was 0.83 m/s, whereas EINT exhibited a median maximum local in-plane leaflet velocity of 0.37 m/s. EINT experienced leaflet fluttering during systole with a flapping frequency of 36 Hz.

From the *Institute of Fluid Dynamics, ETH Zürich, Sonneggstrasse 3, 8092 Zurich, Switzerland

ARTORG Center, University of Bern, Murtenstrasse 50, 3008 Bern, Switzerland

Department of Cardiovascular Surgery, University Hospital Bern, Bern, Switzerland.

Submitted for consideration March 2017; accepted for publication in revised form August 2017.

All authors declare that they have no conflict of interest that may bias this work. The research in this work was funded with internal funds from ETH Zürich and the University of Bern.

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Correspondence: Bernhard Vennemann, Institute of Fluid Dynamics, ETH Zürich, Sonneggstrasse 3, 8092 Zurich, Switzerland. Email:

Copyright © 2018 by the American Society for Artificial Internal Organs