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Human Umbilical Vessels: Choosing the Optimal Decellularization Method

Rodríguez-Rodríguez, Victor E.; Martínez-González, Brenda; Quiroga-Garza, Alejandro; Reyes-Hernández, Cynthia Guadalupe; de la Fuente-Villarreal, David; de la Garza-Castro, Oscar; Guzmán-López, Santos; Elizondo-Omaña, Rodrigo Enrique

doi: 10.1097/MAT.0000000000000715
Review Articles

There is an increasing demand of small-diameter vascular grafts for treatment of circulatory pathologies. Decellularization offers the possibility of using human blood vessels as scaffolds to create vascular grafts. Umbilical vessels have great potential because of their availability and morphological characteristics. Various decellularization techniques have been used in umbilical vessels, but consensus on which is the most appropriate has not yet been reached. The objective of this review is to analyze the morphological and biomechanical characteristics of decellularized human umbilical arteries and veins with different techniques. Evidence indicates that the umbilical vessels are a viable option to develop small-diameter vascular grafts. Detergents are the agents most often used and with most evidence. However, further studies are needed to accurately analyze the components of the extracellular matrix and biomechanical characteristics, as well as the capacity for recellularization and in vivo functionality.

From the Human Anatomy Department, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Monterrey N.L., Mexico.

Submitted for consideration July 2017; accepted for publication in revised form October 2017.

Disclosure: The authors have no conflicts of interest to report.

Correspondence: Alejandro Quiroga-Garza, MD, Departamento de Anatomía Humana, Facultad de Medicina, Universidad Autónoma de Nuevo León (UANL), Ave. Madero y Dr. Aguirre Pequeño S/N, Colonia Mitras Centro, Monterrey N.L., C.P. 64460, México. Email: dr.aquirogag@gmail.com.

Copyright © 2018 by the American Society for Artificial Internal Organs