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KAWAI TOSHINORI; ANNICH, GAIL M.; MEINHARDT, JÜRGEN P.; ICHIBA, SHINGO; BRANT, DAVID O.; BARTLETT, ROBERT H.
ASAIO Journal: September-October 1999
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Blood flow is believed to affect the thrombogenicity of extra-corporeal circulation (ECC). The purpose of this study was to look at the relationship between blood flow and thrombogenicity in a rabbit model of ECC. Rabbits were anesthetized and systematically heparinized. Bilateral jugular cannulation was performed, and the animals were placed on venovenous ECC. The circuits were composed of 1 m of 1/4 inch size surgical grade polyvinylchloride (PVC) tubing. ECC was maintained for 4 hours. Three experimental groups were studied: a high flow group (n = 7; flow rate: 30 ml/min/Kg), low flow group (n = 7; flow rate: 10 ml/mg/Kg), and no ECC group (n = 7). Platelet count, fibrinogen concentration, PaO2/FiO2, and postmortem findings were evaluated. Platelet consumption was higher with high flow, and fibrinogen consumption was higher with low flow.

Copyright © 1999 by the American Society for Artificial Internal Organs