ORIGINAL ARTICLE: PDF OnlyTATSUMI EISUKE; NAKAMURA, MAKOTO; MASUZAWA, TORU; TAENAKA, YOSHIYUKI; SOHN, YOUNG-SANG; NISHIMURA, TAKASHI; NAKATA, MASAKO; NAKATANI, TAKESHI; OHNO, TAKASHI; ENDO, SEIKO; TAKIURA, KOKI; TAKEWA, YOSHIAKI; KAKUTA, YUKIHIDE; TAKANO, HISATERUASAIO Journal: September-October 1997 - p M625 Free Abstract The authors evaluated the basic performance of an interatrial shunt (IAS) made by punching a hole in the atrial septum, in accommodating the left-right imbalance in our electrohy-draulic total artificial heart (EHTAH) system. In an in vitro study conducted in a closed mock circuit connected with the EHTAH, the interatrial pressure gradient changed in compliance with the amount of bronchial flow and the size of the IAS. The IAS of 4.4 mm diameter or larger maintained the interatrial pressure gradient within physiologically permissible limits when the amount of bronchial flow was 5% of cardiac output or less. A left-to-right one-way valve made of a piece of pericardium, a possible option in this IAS method, successfully prevented right-to-left reverse shunt flow through the IAS. In a chronic in vivo study using a calf implanted with the EHTAH for 10 days, a 4.5 mm IAS without the one-way valve demonstrated satisfactory dynamic left-right balancing capacity with a stable interatrial pressure gradient of 4 ± 1 mmHg over a wide range of atrial pressures. No thrombus was found in or around the IAS at autopsy. The authors conciude that the IAS is a simple and promising means © Lippincott-Raven Publishers.