Secondary Logo

Journal Logo

CASE REPORTS

Crossed testicular ectopia

a case report and review of the literature

Salah, Sami E.E.; Elhaj, Khalid I.; Awadelseed, Yasir O.M.; Mohammed, Sami G.E.E.

Author Information
doi: 10.1097/01.XPS.0000491016.20793.4e
  • Free

Abstract

Introduction

There are five known types of testicular ectopia: superficial, inguinal (interstitial), pubopenile, perineal femoral (crural), and crossed. Crossed testicular ectopia (CTE) is a rare congenital anomaly and is also referred to as unilateral double testis, testicular pseudoduplication, and transverse aberrant testicular maldescent. The testis may fail to descend completely along its normal path from the retroperitoneum to the scrotum (cryptorchidism). The abnormalities associated with CTE are persistent Müllerian duct syndrome, true hermaphrodites, inguinal hernia, hypospadias, pseudohermaphroditism, and scrotal anomalies. Herein, we present a 2-year-old boy with left inguinal hernia and contralateral nonpalpable testis, and review literature.

Case report

A 2-year-old boy presented with a swelling in the left groin and an empty scrotum on the right side. Family history was insignificant and examination of other systems proved normal. Physical signs showed left inguinoscrotal hernia with easily reducible content. External genitalia were of male type, and circumcision had not been performed. The right hemiscrotum was empty with normal-appearing urethral meatus. The left testis was palpated in the scrotum. The right testis was not visualized by ultrasonography. During laparoscopy, the right side was completely obliterated with no vas or gubernaculums. The right testis was not found in the posterior abdominal wall. On the left side there was a hernia that was exaggerated by the pneumoperitoneum with a testicle inside; however, its blood supply was coming from the right side. The testicle was reduced into the abdominal cavity and it was clearly originating from the right side; next, external pressure was applied to the hernia and the left testicle comes in view (Fig. 1). CTE was subsequently diagnosed (Fig. 2).

Fig. 1
Fig. 1:
Laparoscopic view of the crossed ectopic testis.
Fig. 2
Fig. 2:
Illustration showing crossed ectopic testis.

Biopsies were taken from a tissue that resembled a rudimentary uterus between the testicles. The two testes were of good size and were identical in appearance. Each had its own vascular pedicle and vas deferens. A biopsy was taken from the testes following herniotomy and high ligation (Fig. 3). The ectopic gonad was fixed to the opposite hemiscrotum through a trans-septal route (Fig. 4). As the cord structures had adequate length, no difficulty was encountered in the procedure. The patient made an uneventful recovery.

Fig. 3
Fig. 3:
Showing the two testis after conversion to open left inguinal exploration.
Fig. 4
Fig. 4:
Postoperative view of trans-septal orchiopexy.

Discussion

CTE is an extremely rare congenital anomaly of testicular ectopia. More than 100 cases have been reported in the literature 1, as it was first described by Von Lenhossek 2, who suggested abnormal gubernaculum testis as a cause.

The mean age at presentation is 4 years. The clinical presentation generally includes an inguinal hernia on one side and a contralateral or sometimes a bilateral cryptorchidism 3,4 (Fig. 2). However, presentation with an obstructed inguinal hernia that cannot be reduced is known 5,6.Thus, it will be beneficial to keep this rare clinical entity in mind, in cases of incarcerated inguinal hernia with contralateral undescended testis.

Usually, the correct diagnosis is not made before surgical exploration, and in cases in which laparoscopic search is not the initial procedure the diagnosis is revealed during open herniotomy 4. Preoperative diagnosis is possible using ultrasound 7, and the value of an experienced sonologist cannot be overstated. MRI is useful when the testis is not detected by ultrasound 8; the only problem is the high cost.

Several authors have explored different theories to understand the development of CTE. One theory proposed the possibility of the development of both testes from the same genital ridge 9; however, Kimura 10 stated that true CTE occurs only if there are two distinct deferent ducts, and a common duct suggests the development of the testis from one genital ridge. Gupta and Das 11 postulated that earlier adherence and fusion of the developing Wolffian ducts might lead to the descent of one testis causing the second one to follow. Another theory states that in cases that present persistent Müllerian duct syndrome the crossed ectopia is caused by the traction exercised on the testis by the Müllerian duct. Frey and Rajfer 12 noted that defective ipsilateral gubernacular development might predispose to CTE.

CTE has been classified into three types: type 1, accompanied only by hernia (40–50%); type 2, accompanied by persistent or rudimentary Müllerian duct structures (30%); and type 3, associated with disorders other than persistent Müllerian remnants (inguinal hernia, hypospadias, pseudohermaphroditism, and scrotal abnormalities) (20%). According to that classification, our case was type 1 CTE. On extremely rare occasions, the vas deferens are fused, a situation that may hinder the testis from being placed into the scrotum during orchiopexy 13. The CTE and testicular duplication should be differentiated. In case of duplication, both testicles arise from the same genital ridge, and they have a common deferent duct and blood supply 8.

In 2–97% of patients with CTE, disorders of the upper and lower urinary tract system have been reported 14. Laparoscopy is useful for both diagnosis and treatment of CTE and associated anomalies 15. Patients with CTE are at an increased risk of malignant transformation. The overall incidence of malignant transformation is 18% 16. There have been reports of embryonal carcinoma 17, seminoma, yolk sac tumor 18, and teratoma 16.

The treatment of transverse testicular ectopia is focused on the detection of associated congenital abnormalities and placement of ectopic testicles into anatomical positions. This preserves fertility and allows monitoring for the development of malignancy. If two gonads come into view during exploration of one inguinal side, intraoperative intra-abdominal evaluation via mini laparotomy allows for the detection of Müllerian structures and genitourinary congenital abnormalities. A biopsy should be taken from tissue remnants between the cord structures or from the abdomen. There is no report of malignancy arising from the retained Müllerian structures. Therefore, routine hysterectomy is not recommended in patients who have obvious uterus and fallopian tubes. Extensive dissection of vas deferens and excision of persistent Müllerian duct structures should be avoided to prevent injury 19.

There were two options for orchiopexy – extraperitoneal orchiopexy and trans-septal orchiopexy – in the papers that reported 147 cases, which was the highest number reported 20,21. In the extraperitoneal technique, the testis is brought to the contralateral hemiscrotum after its passing near the root of the penis. In the trans-septal technique, the testis should traverse the scrotal mediastinum to be fixed in it (Fig. 5).

Fig. 5
Fig. 5:
Illustration of trans-septal orchiopexy.

Conclusion

CTE is a rare anomaly for which the pathogenesis remains unclear. The diagnosis should be suspected when there is unilateral hernia and concurrent contralateral cryptorchidism. In suspected cases, an appropriate ultrasonographic evaluation to rule out other potential abnormalities is indicated. Laparoscopy is valuable for both diagnosis and management of CTE and associated anomalies. Trans-septal orchiopexy is highly recommended to manage CTE.

Acknowledgements

Conflicts of interest

There are no conflicts of interest.

References

1. Fourcroy JL, Belman AB. Transverse testicular ectopia with persistent Müllerian duct. Urology 1982; 19:536–538.
2. Von Lenhossek MN. Ectopia testis transverse. Anat Anz 1886; 1:376–381.
3. Feizzadeh Kerigh B, Mohamadzadeh Rezaei M. Crossed testicular ectopia: a case report. Urol J 2005; 2:222–223.
4. Acikalin MF, Pasaoglu O, Tokar B, Ilgici D, Ilhan H. Persistent Müllerian duct syndrome with transverse testicular ectopia: a case report with literature review. Turk J Med Sci 2004; 34:333–336.
5. Oludiran OO, Sakpa CL. Crossed ectopic testis: a case report and review of the literature. Pediatr Surg Int 2005; 21:672–673.
6. Tatli D, Numanoglu KV. Transverse testicular ectopia associated with incarcerated inguinal hernia: a case report. Cases J 2008; 1:200.
7. Nam YS, Baik HK, Kim SJ, Lee HK, Park HK. Transverse testicular ectopia found by preoperative ultrasonography. J Korean Med Sci 1998; 13:328–330.
8. Gothi R, Aggarwal B. Crossed ectopia of the left testis detected on MRI. Am J Roentgenol 2006; 187:W320–W321.
9. Berg AA. VIII. Transverse ectopy of the testis. Ann Surg 1904; 40:223–224.
10. Kimura T. Transverse ectopy of the testis with masculine uterus. Ann Surg 1918; 68:420–425.
11. Gupta RL, Das P. Ectopia testis transverse. J Indian Med Assoc 1960; 35:547–549.
12. Frey HL, Rajfer J. Role of the gubernaculum and intraabdominal pressure in the process of testicular descent. J Urol 1984; 131:574–579.
13. Chacko JK, Furness PD III, Mingin GC. Presentation of fused vas deferens. Urology 2006; 67:1085.e17–1085.e18.
14. Tolete-Velcek F, Bernstein MO, Hansbrough F. Crossed testicular ectopia with bilateral duplication of the vasa deferentia: an unusual finding in cryptorchidism. J Pediatr Surg 1988; 23:641–643.
15. Gornall PG, Pender DJ. Crossed testicular ectopia detected by laparoscopy. Br J Urol 1987; 59:283.
16. Berkmen F. Persistent Müllerian duct syndrome with or without transverse testicular ectopia and testis tumours. Br J Urol 1997; 79:122–126.
17. Melman A, Leiter E, Perez JM, Driscoll D, Palmer C. The influence of neonatal orchiopexy upon the testis in persistent Müllerian duct syndrome. J Urol 1981; 125:856–858.
18. Eastham JA, McEvoy K, Sullivan R, Chandrasoma P. A case of simultaneous bilateral nonseminomatous testicular tumors in persistent Müllerian duct syndrome. J Urol 1992; 148 (Pt 1):407–408.
19. Karnak I, Tanyel FC, Akçören Z, Hiçsönmez A. Transverse testicular ectopia with persistent Müllerian duct syndrome. J Pediatr Surg 1997; 32:1362–1364.
20. Esteves E, Pinus J, Maranhão RF, Abib Sde C, Pinus J. Crossed testicular ectopia. Sao Paulo Med J 1995; 113:935–940.
21. Pandey A, Gupta DK, Gangopadhyay AN, Sharma SP. Misdiagnosed transverse testicular ectopia: a rare entity. Hernia 2009; 13:305–307.
© 2016 Annals of Pediatric Surgery