According to the US Renal Data System and the North American Pediatric Renal Transplant Cooperative Study, ∼5000 children younger than 20 years of age and approximately 200 children younger than 2 years of age are being treated annually for end-stage renal disease (ESRD) 1.
Peritoneal dialysis (PD) was first introduced in 1978 and has become the best renal replacement management modality in children with ESRD awaiting renal transplantation 2. It is now a safe, effective, and well-tolerated form compared with hemodialysis, which requires child admission as an inpatient or clinic attendance as an outpatient for up to 4 h a day, 3 days every week. Nevertheless, PD can be performed at home by caregivers with minimum training 3.
Peritoneal dialysis catheter (PDC)-related complications and failure still remain a common clinical problem in pediatric patients and is as high as 70% in some series despite advancements in PDC placement and dialysis techniques 3. There are multiple perioperative and patient-related factors affecting PDC survival, including operative technique, catheter selection, and patient variables that may influence catheter lifespan. There exists uncertainty regarding the optimal approach for surgical placement of PDC in children, and this is proven by the American Pediatric Surgical Association and the Canadian Association of Pediatric Surgeons 4.
Our aim in this study was to analyze the risk factors that may lead to PDC failure in children with ESRD, especially those factors that could be potentially modified to minimize PDC failures.
Patients and methods
A retrospective chart review was conducted on 31 patients of less than 12 years of age who had ESRD on whom a total of 54 operative PDC placements were carried out at the tertiary Children’s Hospital, King Fahad Medical City, Riyadh, Saudi Arabia, from January 2007 to December 2010. Institutional Review Board approval was obtained. The data included patient demographics, serum albumin level, PDC details, types of surgery techniques, reasons for failure, and removal. These data identify perioperative and operative factors associated with failure and nonfailure groups. We did not consider a catheter as having failed if it was functioning when removed following successful renal transplantation or death.
The data were extracted from medical records according to a set proforma and entered into the Access database. Analysis was conducted using statistical software SPSS 18.0 (SPSS Inc., Chicago, Illinois, USA). Median [interquartile range (IQR)] was presented for age and weight, and categorical data were presented in the form of frequencies (percentages). Age and weight were compared between the two groups using the Mann–Whitney U-test, whereas categorical variables were compared using either the χ 2 or Fisher’s exact test, as appropriate. P value less than or equal to 0.05 was considered statistically significant.
Fifty-four PDCs were inserted in 31 pediatric patients with ESRD, of whom 17 (55%) were boys and 14 (45%) were girls; median (±IQR) age was 3.8 (±6.5) years and weight was 15.5 (±20) kg. Patients with median age 1.8 (±5) showed significant PDC failure compared with patients with median age 5 (±7.8), (P=0.007), whereas weight did not show a significant effect on PDC failure (P=0.085). Sixteen (52%) patients underwent a single PDC placement, 11 (35%) underwent two PDC placements, two (6.5%) underwent three PDC placements, one underwent four placements, and another one underwent six PDC placements. The causes of ESRD included six cases of renal dysplasia/hypoplasia (19.3%), five cases of congenital nephrotic syndrome (16.1%), five cases of reflux nephropathy (16.1%), three cases of obstructive uropathy (9.7%), and three cases each of focal glomerular sclerosis, glomerular nephropathy, hereditary nephropathy, and idiopathy (9.7%).
All PDCs were inserted by laparotomy and the patients were divided into two groups: the nonfailure group (NFG) comprising 31 (57.4%) patients and the failure group (FG) comprising 23 (42.5%) patients. The types of PDCs used are summarized in Table 1 and showed a highly significant PDC failure (P=0.009). Supraumbilical paramedian abdominal entry incisions were used in 49 (90.7%) patients with no peritoneal leakage. Simultaneous omentectomy (SO) was performed in 34 (62.9%) patients and was associated with a lower PDC failure rate compared with when no simultaneous omentectomy was performed [20 (37%) patients; P<0.001]. All PDC tips were placed in the pelvis and tunneled above the fascia before exiting at the skin site that was oriented downward in 32 (59%) patients and was associated with a lower PDC failure rate than when oriented upward in 22 (40.7%) patients, which showed a highly significant association with PDC failure (P<0.001).
The causes of 23 PDC failures included 13 (56.5%) cases of idiopathic peritonitis, five (21.7%) cases of PDC occlusion by omentum, four (17.4%) cases of PDC malposition, and one (4.4%) case of PDC external tube leakage from a hole induced by the patient himself. Peritonitis was proven by peritoneal culture in 17 PDCs (31.4%), including three (17.6%) fungal, four (23.5%) Staphylococcus aureus, two (11.8%) Staphylococcus epidermidis, one (5.9%) Pseudomonas aeruginosa, and seven (41.2%) due to other bacteria. Peritonitis was significantly associated with PDC failure (P<0.001). There was no significant difference in serum albumin levels between the two groups at the time of PDC insertion (P=0.400).
Among the FG, 13 PDCs (56.5%) were removed and new PDCs were inserted at the same time; eight (34.8) cases were managed by antirenal failure medication until reinsertion and two (8.7%) PDCs were shifted temporarily to hemodialysis until infection could be controlled and a PDC could be reinserted. However, in NFG, 28 patients (90.3%) were on regular follow-up, two patients were transferred to another hospital for renal transplantation, and one patient died after 1 year from PDC insertion (not dialysis related). Salvage from failure was carried out for 10 PDCs. Five PDCs were salvaged from peritonitis failure by proper medical management: one in NFG and two in FG in whom the PDC was salvaged twice. The other five PDCs were salvaged by laparoscopy (three omentum occlusion and two due to malposition): one in NFG and two in FG in whom the PDC was salvaged twice.
PD is used for renal replacement therapy in over 25 000 patients in the USA 5. Placing PDC in children poses unique challenges, which are reflected in the high complication rates among children and are as high as 70% in some series 3.
Our study agrees with many recent studies 6,7 on the use of paramedian entry incision, SO, and downward exit site orientations in PDC. Chest wall location for the exit site is preferred in infants wearing diapers, in obese infants, and in those with ostomies 8. Laparoscopy was used in adults and children to rescue the blocked PDC and later for initial placement 9,10. In our study, laparoscopy was used primarily to rescue five blocked/misplaced PDCs. In accordance with the study by Cribbs et al. 3, PDC-related complications and failures were more during young age, especially in those less than 1 year and less than 10 kg.
Our findings corroborate those of previous studies claiming that use of the curled tip, swan-neck, and double-cuff PDC with downward exit delays the time to the first episode of peritonitis in children 11,12. In contrast, Macchini et al. 7 had 89 PDCs implanted surgically with SO in 78 pediatric patients over a 16-year period. They found that a single-cuff catheter had a lower infection rate compared with a double-cuff catheter (P=<0.01). However, Cribbs et al. 3 performed 121 PDCs in 81 patients and found that curled catheters offered no advantage against occlusion compared with straight catheters.
Despite the improvements observed in survival after catheter placement over the past several years, PDC infection and malfunction were confirmed to be the most common complications leading to PDC failure 6,7,13. In our study, idiopathic peritonitis was the first cause of PDC failure (P<0.001). Recurrent peritonitis may lead to irreversible change in peritoneal membrane function, resulting in permanent PD failure 14; this may explain recurrent PDC peritonitis failures in two of our patients (four times and six times). Many recent studies recommend procedures that may reduce the rate of peritonitis, such as preoperative antibiotic prophylaxis, continuous medical education for the dialysis personnel and parents, intensive training flush before fill dialysis delivery systems, the double-bag connecting system, careful handwashing habits, treatment of nasal carriage of S. aureus, and early treatment of exit site infections 2.
In accordance with Rinaldi et al.’s 6 study, the second most common cause of PDC failure in our study was PDC obstruction (21.7%). In our study, PDC tip malposition occurred in 17.4% of patients and was one of the causes of PDC failure as a result of impaired dialysate outflow that needed replacement and insertion of new PDCs. Chen and Cheng 15 carried out a simple suture fixation technique of the catheter tip in 38 patients that successfully prevented catheter tip migration .
Serum albumin is a marker for malnutrition and also one of the factors predisposing to infection in uremic and dialysis patients. In our study there was no significant difference in serum albumin levels between the two groups at the time of PDC insertion (P=0.400). However, in a study by Wong and colleagues among 1723 children, the researchers found that patients with hypoalbuminemia who were less than 18 years of age at the time of initiating dialysis are at a higher risk for death, and each reduction in serum albumin levels by 1 g/dl at the start of dialysis was associated with a 54% higher risk of death. This result was independent of other potential confounding variables. Hence, the prevention of malnutrition and associated hypoalbuminemia is critical for the improvement of long-term outcome and achievement of optimal growth in children on dialysis 16.
The methods for placement of PDC include the traditional open surgical technique, consisting commonly of a minilaparotomy, the percutaneous Seldinger technique, and recently laparoscopy 17–19. Each of these techniques is associated with both potential advantages and disadvantages, and, when considering which insertion technique is best, cost-effectiveness, morbidity, and functional outcome should be considered 17. In our study, we cannot give statistically comparative values because we used the open surgical technique in all PDC placements.
Our study provides some recommendations to minimize PDC failures, which include improvement of patients’ nutritional status, use of a swan-neck double-cuffed catheter, paramedian abdominal entry incision, SO, downward orientation of the exit site, and use of an up-to-date technique by a dedicated team for proper use of PDC. However, prospective studies possibly on a multicentric basis are necessary to standardize the best PDC insertion and maintenance techniques to minimize PDC failures and improve quality of life for children with ESRD.
We extend our thanks to all pediatric surgery team and our team in the Research and Scientific Publication Center, Academic and Training Affairs, King Fahad Medical City for their support which allow this paper to see the light.
Conflicts of interest
There are no conflicts of interest.
1. Velasco RF, Mun~oz JL, Saavedra VS, Mena Brito Trejo JE, Qureshi AR, García López E, et al. Automated peritoneal dialysis as the modality of choice: a single-center, 3-year experience with 458 children in Mexico. Pediatr Nephrol. 2008;23:465–471
2. Rahim KA, Seidel K, McDonald RA. Risk factors for catheter-related complications in pediatric peritoneal dialysis. Pediatr Nephrol. 2004;19:1021–1028
3. Cribbs RK, Greenbaum LA, Heiss KF. Risk factors for early peritoneal dialysis catheter failure in children. J Pediatr Surg. 2010;45:585–589
4. Washburn KK, Currier H, Salter KJ, Brandt ML. Surgical technique for peritoneal dialysis catheter placement in the pediatric patient: a North American survey. Adv Perit Dial. 2004;20:218–221
5. Gajjar AH, Rhoden DH, Kathuria P, Kaul R, Udupa AD, Jennings WC. Peritoneal dialysis catheters: laparoscopic versus traditional placement techniques and outcomes. Am J Surg. 2007;194:872–876
6. Rinaldi S, Sera F, Verrina E, Edefonti A, Gianoglio B, Perfumo F, et al. Chronic peritoneal dialysis catheters in children: a fifteen-year experience of the Italian registry of pediatric chronic peritoneal dialysis. Perit Dial Int. 2004;24:481–486
7. Macchini F, Valadè A, Ardissino G, Testa S, Edefonti A, Torricelli M, et al. Chronic peritoneal dialysis in children: catheter related complications. A single centre experience. Pediatr Surg Int. 2006;22:524–528
8. Dell'Aquila R, Chiaramonte S, Rodighiero MP, Spano E, Di Loreto P, Kohn CO, et al. Rational choice of peritoneal dialysis catheter. Perit Dial Int. 2007;27(Suppl 2):S119–S125
9. Mattioli G, Castagnetti M, Verrina E, Trivelli A, Torre M, Jasonni V, et al. Laparoscopic-assisted peritoneal dialysis catheter implantation in pediatric patients. Urology. 2007;69:1185–1189
10. Stringel G, McBride W, Weiss R. Laparoscopic placement of peritoneal dialysis catheters in children. J Pediatr Surg. 2008;43:857–860
11. Shroff R, Ledermann S. Long-term outcome of chronic dialysis in children. Pediatr Nephrol. 2009;24:463–474
12. Lo WK, Lui SL, Li FK, Choy BY, Lam MF, Tse KC, et al. A prospective randomized study on three different peritoneal dialysis catheters. Perit Dial Int. 2003;23(Suppl 2):S127–S131
13. Chadha V, Schaefer FS, Warady BA. Dialysis-associated peritonitis in children. Pediatr Nephrol. 2010;25:425–440
14. Auron A, Simon S, Andrews W, Jones L, Johnson S, Musharaf G, et al. Prevention of peritonitis in children receiving peritoneal dialysis. Pediatr Nephrol. 2007;22:578–585
15. Chen WM, Cheng CL. A simple method to prevent peritoneal dialysis catheter tip migration. Perit Dial Int. 2007;27:554–556
16. Wong CS, Hingorani S, Gillen DL, Sherrard DJ, Watkins SL, Brandt JR, et al. Hypoalbuminemia and risk of death in pediatric patients with end-stage renal disease. Kidney Int. 2002;61:630–637
17. Lu CT, Watson DI, Elias TJ, Faull RJ, Clarkson AR, Bannister KM. Laparoscopic placement of peritoneal dialysis catheters: 7 years experience. ANZ J Surg. 2003;73:109–111
18. Caliskan K, Nursal TZ, Tarim AM, Noyan T, Moray G, Haberal M. The adequacy of laparoscopy for continuous ambulatory peritoneal dialysis procedures. Transpl Proc. 2007;39:1359–1361
19. Copeland DR, Blaszak RT, Tolleson JS, Saad DF, Jackson RJ, Smith SD, et al. Laparoscopic Tenckhoff catheter placement in children using a securing suture in the pelvis: comparison to the open approach. J Pediatr Surg. 2008;43:2256–2259