Online Articles: Research ArticlesValosin-containing Protein in Psoriasis: A Clinical and Immunohistochemical StudyEl Dein Mohamed, Asmaa Shams. MD*; Hagag, Magda M. MD†; Kassem, Naira Mohamed Abd El-Aziz MBBCh†; Shehata, Wafaa A. MD†Author Information Departments of *Pathology †Dermatology and Andrology, Faculty of Medicine, Menoufia University, Egypt The authors declare no conflict of interest. Reprints: Asmaa S. El Dein Mohamed, MD, Department of Pathology, Faculty of Medicine, Menoufia University, Abou Obeida Ben Al Garah, Shebin El Kom, Menoufia Governorate 32511, Egypt (e-mail: [email protected]). Applied Immunohistochemistry & Molecular Morphology: September 2021 - Volume 29 - Issue 8 - p e68-e72 doi: 10.1097/PAI.0000000000000944 Buy Metrics Abstract Psoriasis is a chronic immune-mediated inflammatory skin disease, affects about 2% to 3% of the world population. Valosin-containing protein (VCP) is one of the newly discovered markers that is highly expressed in neoplasms and hyperproliferative lesions. This work aimed to study the role of VCP in psoriasis vulgaris by immunohistochemical study and correlate its expression with the available clinicopathologic data. This prospective case-control study was conducted on 25 patients with psoriasis vulgaris and 25 age-matched and sex-matched healthy individuals as a control group. Skin biopsies were taken under local anesthesia from cases and controls. VCP immunoreactivity showed that epidermal VCP expression had a significant stepwise increase (P=0.002) from control to lesional psoriatic sections. Epidermal VCP H-score was significantly associated with the progressive course (P=0.037). Similarly, VCP in the dermis showed a significant expression in lesional psoriatic skin (P≤0.001). Higher VCP in the dermis in cases with a history of joint affection (P<0.05) was detected. We concluded that VCP is a promising marker for follow-up and monitoring of psoriatic patients and may play a role as a therapeutic target. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.