Review ArticleImmunohistochemistry in the Postmortem Diagnosis of Sepsis: A Systematic ReviewBarranco, Rosario MD; Ventura, Francesco PhD, MDAuthor Information Department of Legal and Forensic Medicine, University of Genova, Genova, Italy The authors declare no conflict of interest. Reprints: Francesco Ventura, PhD, MD, Department of Legal and Forensic Medicine, University of Genova, via De’ Toni 12, 16132 Genova, Italy (e-mail: [email protected]). Applied Immunohistochemistry & Molecular Morphology: September 2020 - Volume 28 - Issue 8 - p 571-578 doi: 10.1097/PAI.0000000000000790 Buy Metrics Abstract It is not uncommon for the forensic pathologist to question whether a deceased person had experienced sepsis that could have either been the cause of or contributed to the person’s death. Often, the missing typical pathologic factors or lack of clinical and circumstantial information on the death render the autopsy of a sepsis-related death a difficult task for the forensic pathologist. Several authors emphasize on how an immunohistochemical analysis could help in diagnosing death related to sepsis. The research we carried out analyzes the main scientific studies in the literature, primarily the tracing of 21 immunohistochemical antigens evaluated to help diagnose death related to sepsis. The purpose of this review was to analyze and summarize the markers studied until now and to consider the limitations of immunohistochemistry that currently exist with regard to this particular field of forensic pathology. Immunohistochemistry provided interesting and promising results, but further studies are needed in order for them to be confirmed, so that they may be applied in standard forensic practice. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.