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The Inflammatory Milieu of Eosinophilic Esophagitis

A Contemporary Review With Emphasis in Putative Immunohistochemistry and Serologic Markers

Lepe, Marcos MD*,†; O’Connell, David ScB; Lombardo, Kara A. BSc*,†; Herzlinger, Michael MD§; Mangray, Shamlal MBBS*,†; Resnick, Murray B. MD, PhD*,†; Matoso, Andres MD*,†

Applied Immunohistochemistry & Molecular Morphology: August 2018 - Volume 26 - Issue 7 - p 435–444
doi: 10.1097/PAI.0000000000000450
Review Article

Eosinophilic esophagitis is a chronic disease characterized by esophageal dysfunction, frequent clinical history of atopy, and eosinophilic inflammation of the esophagus. Within the esophageal mucosa, there is a wide variety of immune mediators, chemotactic factors, mediators of transcription, and markers of epithelial differentiation and integrity that are overexpressed or underexpressed in eosinophilic esophagitis, offering many candidates for biomarkers with diagnostic or prognostic potential. In this review, we summarize the results from studies performed so far to evaluate the detection of these markers by immunohistochemistry on esophageal biopsies. In addition, we briefly describe some attempts to identify markers that could be detected in serum to be used to diagnose or monitor the disease without the need of a biopsy.

Departments of *Pathology and Laboratory Medicine

§Pediatrics, Rhode Island Hospital

Brown University Alpert Medical School

Department of Biology, Brown University, Providence, RI

M.L. and D.O'C. contributed equally to this work.

The authors declare no conflict of interest.

Reprints: Andres Matoso, MD, Rhode Island Hospital, 593 Eddy Street, APC12-204, Providence, RI 02903 (e-mail:

Received August 4, 2016

Accepted August 25, 2016

Copyright 2018 Wolters Kluwer Health, Inc. All rights reserved.