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Immunohistochemical Expression of MCM-2 in Oral Epithelial Dysplasias

Zakaria, Samar H. MD; Farag, Heba A. PhD; Khater, Dina S. PhD

Applied Immunohistochemistry & Molecular Morphology: August 2018 - Volume 26 - Issue 7 - p 509–513
doi: 10.1097/PAI.0000000000000330
Research Articles

Background: Oral cancer is one of the most frequent cancers in the world. It arises from epithelial dysplasia. Hence, identifying these lesions in an early stage could prevent their malignant transformation. The aim of the present work was to assess the cell proliferative activity of minichromosome maintenance protein (MCM-2) in oral epithelial dysplastic lesions and to correlate the results with different grades of epithelial dysplasia in an attempt to use MCM-2 in the early detection of malignancy.

Methods: MCM-2 expression was determined by the nuclear count in a total of 30 oral epithelial dysplastic specimens roughly classified into 10 cases of mild, moderate, and severe dysplasia. Five cases of early invasive squamous-cell carcinomas and 5 cases of epithelial hyperplasia were also included.

Results: The MCM-2 immunostaining was found to increase gradually from mild to moderate to severe dysplasia and reached its maximum value in early invasive squamous cell carcinoma.

Conclusion: MCM-2 is of prognostic value in cases of oral dysplasia that have a tendency to undergo malignant transformation.

Department of Oral Pathology, Faculty of Oral and Dental Medicine, Cairo University, Giza, Egypt

The authors declare no conflict of interest.

Reprints: Samar H. Zakaria, MD, Department of Oral Pathology, Faculty of Oral and Dental Medicine, Cairo University, 146 Elbahr Elazam Street, Giza, Egypt (e-mail:

Received September 8, 2015

Accepted December 11, 2015

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