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Increased FLI-1 Expression is Associated With Poor Prognosis in Non–Small Cell Lung Cancers

Lin, Shiou-Fu MD; Wu, Chun-Chieh MD; Chai, Chee-Yin MD, PhD

Applied Immunohistochemistry & Molecular Morphology: September 2016 - Volume 24 - Issue 8 - p 556–561
doi: 10.1097/PAI.0000000000000227
Research Articles

Friend leukemia integration-1 (FLI-1) antibody, a commercially available antibody directed against the C-terminus of FLI-1 protein-binding domain, has been used as a useful tool in the differential diagnosis of small blue round cell tumors and vascular neoplasms, but shows inconsistent expression in lung cancers. The aims of this study were to evaluate FLI-1 immunohistochemical expression in non–small cell lung cancer (NSCLC), and its relationships between the clinicopathologic parameters and prognosis. We investigated the FLI-1 expression in 108 cases of NSCLC by using multiple tumor microarrays. Correlations between the FLI-1 expression and clinicopathologic parameters and prognostic significance were analyzed. The effect of FLI-1 expression on survival is estimated by Kaplan-Meier survival analysis and Cox proportional hazards models. Our results revealed that patients with high FLI-1 expression had shorter overall survival (P=0.014) than those with low FLI-1 expression. In multivariate analysis, FLI-1 was confirmed as an independent poor prognostic factor in NSCLC (overall survival: hazard ratio, 7.292; 95% confidence interval, 0.294-0.823; P=0.007). In conclusion, this study shows that FLI-1 is expressed variably in different subtypes of NSCLC, and its expression is related to clinicopathologic parameters and poorer prognosis. However, further studies are required to elucidate its function in tumorigenesis of NSCLC.

*Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University

Department of Pathology, Faculty of Medicine, Kaohsiung Medical University

§Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung City, Taiwan

Supported by a Grant from the Kaohsiung Medical University Research Foundation (KMU-M103025).

The authors declare no conflict of interest.

Reprints: Chee-Yin Chai, MD, PhD, Department of Pathology, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Kaohsiung City 807, Taiwan (e-mail:

Received December 5, 2014

Accepted April 29, 2015

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