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Hepatoid Adenocarcinoma of the Ureter: Unusual Case Presenting Hepatic and Ovarian Metastases

Rotellini, Matteo MD*; Messerini, Luca MD*; Stomaci, Niceta MD; Raspollini, Maria Rosaria MD, PhD

Applied Immunohistochemistry & Molecular Morphology: October 2011 - Volume 19 - Issue 5 - p 478–483
doi: 10.1097/PAI.0b013e318216af63
Case Report

Hepatoid adenocarcinoma is a rare neoplasm, which has a striking morphologic similarity to hepatocarcinoma. It has been described in different organs, the most common are stomach, lung, and pancreas. In some cases, it is characterized by high serum levels of α-fetoprotein. This tumor has a pattern similar to the hepatocarcinoma. The typical features are a combination of histopathologic aspects of solid nests and trabecular structures of polygonal atypical cells with eosinophil and granular cytoplasm and immunohistochemical expression of α-fetoprotein and of carcinoembryonic antigen in half of cases. Here, we report the case of an old female patient affected by hepatoid adenocarcinoma of the ureter with ovarian, small intestine, and hepatic involvement. We discuss the clinical aspects, the morphologic features, and the immunoistochemical staining useful for differential diagnosis.

Divisions of Histology and Molecular Diagnostics

*Pathology, Department of Critical Care Medicine and Surgery

Urology, University Hospital Careggi, University of Florence, Florence, Italy

The authors declare no conflict of interest.

Reprints: Maria Rosaria Raspollini, MD, PhD, Division of Histology and Molecular Diagnostics, University Hospital Careggi, Viale G.B. Morgagni, 85. 50134 Florence, Italy (e-mail:

Received January 5, 2011

Accepted February 21, 2011

© 2011 Lippincott Williams & Wilkins, Inc.