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Clear Cell Carcinoma of the Bladder in a Patient With a Earlier Clear Cell Renal Cell Carcinoma: A Case Report With Morphologic, Immunohistochemical, and Cytogenetical Analysis

Rotellini, Matteo MD*; Fondi, Cristina MD*; Paglierani, Milena BSc*; Stomaci, Niceta MD; Raspollini, Maria Rosaria MD, PhD*

Applied Immunohistochemistry & Molecular Morphology: July 2010 - Volume 18 - Issue 4 - p 396-399
doi: 10.1097/PAI.0b013e3181d57dce
Case Reports

Clear cell transitional carcinoma of the bladder is a subtype of transitional carcinoma that morphologically resembles a clear cell renal cell carcinoma. Although kidney tumors do not frequently metastasize to the bladder, the recurrence after a clear cell renal cell carcinoma has been reported even several years after nephrectomy. We report the case of a male patient to whom radical nephrectomy for a clear cell renal cell carcinoma has been done, with a bladder tumor featuring polygonal cells with abundant clear cytoplasm deeply infiltrating the vesical wall. We discuss the morphologic features, the immunohistochemical staining with a new marker and the UroVysion FISH analysis to achieve a definitive diagnosis.

Departments of *Human Pathology and Oncology

Urology, University of Florence, Florence, Italy

Reprints: Maria Rosaria Raspollini, MD, PhD, Department of Human Pathology and Oncology, Viale G.B. Morgagni 85, 50134 Florence, Italy (e-mail:

Received for publication November 25, 2009; accepted January 21, 2010

© 2010 Lippincott Williams & Wilkins, Inc.